{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:58:16Z","timestamp":1790621896114,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this study is to compare the safety of ibuprofen and acetaminophen (paracetamol) for acute mild\u2010to\u2010moderate pain in children and adolescents through a systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Scopus and Web of Science were searched from inception to May 2026 for randomized controlled trials (RCTs) in patients aged 0\u201318\u2009years that reported safety outcomes. RCTs enrolling adult or mixed\u2010age populations in acute pain settings were also considered eligible when paediatric\u2010relevant safety data could be extracted. The review was conducted and reported in accordance with the PRISMA 2020 statement. Primary outcomes were total adverse events (AEs), gastrointestinal, renal, hepatic and bleeding events. The risk of bias was assessed using RoB 2. Random\u2010effects meta\u2010analyses were expressed as risk ratios (RR) with 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen studies (2847 patients) were included across postoperative pain, musculoskeletal trauma, orthodontic pain and emergency department settings, with follow\u2010up ranging from single\u2010dose assessments to 12\u2009months. Three studies, including 937 participants, contributed to the primary meta\u2010analysis of any adverse event. Ibuprofen was not associated with a statistically significant difference in the risk of any adverse event compared with acetaminophen (RR 0.80, 95% CI 0.36\u20131.79;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20092.9%). No serious renal or hepatic adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Available RCT evidence did not show a clear difference in short\u2010term safety between ibuprofen and acetaminophen in paediatric and acute pain populations; however, the certainty of the evidence is limited. Patient factors and clinical context should guide drug choice. Larger RCTs with standardized safety reporting are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70693","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:33:12Z","timestamp":1784082792000},"page":"3277-3287","source":"Crossref","is-referenced-by-count":0,"title":["Ibuprofen\n                    <i>vs<\/i>\n                    . acetaminophen for acute mild\u2010to\u2010moderate pain management: A systematic review and meta\u2010analysis of safety with a focus on paediatric populations"],"prefix":"10.1002","volume":"92","author":[{"given":"Gian Luigi","family":"Marseglia","sequence":"first","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Giovanna","family":"Marchisio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"Department of Pediatrics Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio Paolo","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[{"name":"Department of Woman and Child and General and Specialized Surgery University of Campania Luigi Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Schiavetti","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Department of Health Sciences University of Genoa  Genoa Italy"},{"name":"Department of Hygiene IRCCS Azienda Ospedaliera Metropolitana  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-8421","authenticated-orcid":false,"given":"Giorgio","family":"Ciprandi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences University of Molise  Campobasso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2025.01.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010023\u201000562\u20101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010016\u20100302\u20103"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903116255"},{"key":"e_1_2_10_6_1","volume-title":"WHO model list of essential medicines for 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