{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:25:10Z","timestamp":1787012710699,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Vascular endothelial growth factor (VEGF) drives corneal neovascularization (CorNV), yet no anti\u2010VEGF eye drops are clinically available. We report phase I\/IIa trials of KH906, a novel topical anti\u2010VEGF agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Trial 1 was a phase I, open\u2010label, dose\u2010escalation study in healthy adults receiving KH906 at 0.1, 0.5, or 1.0\u2009mg\/mL. Trial 2 was a phase I, multicentre, open\u2010label, dose\u2010escalation study in patients with CorNV at the same doses. Trial 3 was a phase IIa, randomized, double\u2010masked, placebo\u2010controlled study assigning patients 1:1:1 to 0.5\u2009mg\/mL KH906, 1.0\u2009mg\/mL KH906, or placebo. Primary endpoints were safety, tolerability and pharmacokinetics (Trials 1 and 2) and safety, tolerability and efficacy (Trial 3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 10 December 2018 to 16 June 2021, 18 healthy participants and 39 patients with CorNV were enrolled. One treatment\u2010related adverse event occurred: a mild corneal epithelial defect in the 1.0\u2010mg\/mL group in Trial 3. No serious or other drug\u2010related adverse events were observed. In Trial 2, KH906 reduced the CorNV area and vessel length. In Trial 3, at Day 28, mean changes in CorNV area were \u22121.2 (0.8), \u22121.6 (1.1) and \u22120.7 (1.1), and mean changes in CorNV length were \u22128.0 (7.3), \u22126.6 (5.9) and \u22121.7 (7.9), in the 0.5\u2010mg\/mL KH906, 1.0\u2010mg\/mL KH906 and placebo groups, respectively. The 1.0\u2010mg\/mL dose produced greater reduction of the CorNV area than lower doses, indicating a dose\u2013response effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>KH906 appears safe and well tolerated and demonstrates preliminary efficacy in reducing CorNV, with higher doses showing greater effect, supporting further clinical development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70707","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:36:01Z","timestamp":1787009761000},"source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics, safety and preliminary efficacy of conbercept eye drops for corneal neovascularization: Results from phase I\/IIa studies"],"prefix":"10.1002","author":[{"given":"Qi","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology West China Hospital, Sichuan University  Chengdu China"},{"name":"Clinical Trial Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Shu","sequence":"additional","affiliation":[{"name":"Clinical Trial Center West China Hospital, Sichuan University  Chengdu China"},{"name":"Division of Abdominal Tumor Multimodality Treatment, Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlei","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Trial Center West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Pharmacy, NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug West China Hospital, Sichuan University  Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Corneal &amp; External Diseases, Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Pan","sequence":"additional","affiliation":[{"name":"Ophthalmology and Corneology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Pei","sequence":"additional","affiliation":[{"name":"Ophthalmology Department The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hong","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Yang","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ke","sequence":"additional","affiliation":[{"name":"Chengdu Kanghong Biotechnology Co. 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