{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:59:49Z","timestamp":1785225589098,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The cardio\u2013ankle vascular index (CAVI) is a blood pressure\u2010independent marker of arterial stiffness and a well\u2010established predictor of cardiovascular (CV) events. The effects of oral semaglutide, particularly at low doses, on arterial stiffness remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010centre retrospective study included 138 patients with type 2 diabetes mellitus who received oral semaglutide and underwent CAVI assessment at baseline and 6\u2009months. \u0394CAVI was defined as baseline minus follow\u2010up CAVI. Therefore, a positive \u0394CAVI indicates a decrease (i.e., improvement) in arterial stiffness. Semaglutide doses (3, 7 or 14\u2009mg) were determined by treating physicians, and concomitant sodium\u2013glucose cotransporter 2 (SGLT\u20102) inhibitor use was recorded. CV outcomes were monitored for up to 18\u2009months after the 6\u2010month evaluation. A \u0394CAVI of \u22650.2 was defined as an effective response. Multivariable linear regression identified predictors of CAVI improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 61\u2009\u00b1\u200911\u2009years, and 62% were men. The mean body mass index was 28.0\u2009\u00b1\u20094.9\u2009kg\u2009m\n                      <jats:sup>\u22122<\/jats:sup>\n                      (median 27.4, interquartile range 24.7\u201330.8). In multivariable linear regression, concomitant SGLT\u20102 inhibitor use was associated with greater CAVI improvement (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.51, 95% CI 0.05\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Oral semaglutide of 14\u2009mg was associated with greater improvement than 3 and 7\u2009mg, whereas higher baseline CAVI was associated with an attenuated response. Patients with \u0394CAVI \u22650.2 did not show a statistically significant difference in CV events during follow\u2010up compared with those without \u0394CAVI \u22650.2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective cohort, higher dose oral semaglutide, particularly in combination with SGLT\u20102 inhibitors, was associated with favourable changes in arterial stiffness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70710","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:13:37Z","timestamp":1785222817000},"source":"Crossref","is-referenced-by-count":0,"title":["Dose\u2010dependent effects of oral semaglutide on arterial stiffness and the additive role of SGLT\u20102 inhibitors in type 2 diabetes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-3246","authenticated-orcid":false,"given":"Takao","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoma","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Sugimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology IUHW Narita Hospital  Narita 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