{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:02:48Z","timestamp":1785466968824,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007131","name":"Changzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CJ20242020"],"award-info":[{"award-number":["CJ20242020"]}],"id":[{"id":"10.13039\/501100007131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Post\u2010transplant anaemia is common in kidney transplant recipients (KTRs). Roxadustat is a novel renal anaemia therapy, but its efficacy, safety and interaction with tacrolimus (TAC) in KTRs require further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective single\u2010centre cohort study of 145 KTRs with post\u2010transplant anaemia (PTA) (March 2021 to March 2025), stratified by treatment into recombinant human erythropoietin (rhEPO,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200973) and roxadustat (ROX,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972) groups. Endpoints included haemoglobin (Hb) changes, treatment response rates, liver and kidney function markers and TAC pharmacokinetics (trough concentration [C\n                      <jats:sub>0<\/jats:sub>\n                      ], dose [D] and C\n                      <jats:sub>0<\/jats:sub>\n                      \/D ratio) at 1, 3 and 6\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For both groups, at all follow\u2010up points, Hb levels increased significantly from baseline (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05). At 6\u2009months, compared to the rhEPO group, the ROX group showed a significantly higher treatment response rate (\u2206Hb\u2009&gt;\u200910\u2009g\/L: 94.44%\n                      <jats:italic>vs<\/jats:italic>\n                      . 78.08%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004) and greater Hb\u2009&gt;\u2009120\u2009g\/L achievement (80.56%\n                      <jats:italic>vs<\/jats:italic>\n                      . 65.75%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.044). No liver\/kidney adverse effects were observed in either group. TAC exposure was unchanged in the rhEPO group, while in the ROX group, the C\n                      <jats:sub>0<\/jats:sub>\n                      increased significantly at 1 and 3\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05), and C\n                      <jats:sub>0<\/jats:sub>\n                      \/D was prominently higher than baseline at 1, 3 and 6\u2009months (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Roxadustat is an effective oral treatment for PTA, demonstrating superior efficacy to rhEPO at 6\u2009months. However, it is associated with a significant drug\u2013drug interaction that may increase TAC exposure. These findings warrant further prospective studies to validate this drug\u2013drug interaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70713","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:54:50Z","timestamp":1785466490000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of roxadustat for anaemia in kidney transplant recipients and its drug\u2013drug interaction with tacrolimus: A retrospective cohort study"],"prefix":"10.1002","author":[{"given":"Haoran","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Soochow University  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Soochow University  Changzhou China"},{"name":"Department of Pharmacy The First People's Hospital of Changzhou  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Soochow University  Changzhou China"},{"name":"Department of Pharmacy The First People's Hospital of Changzhou  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Soochow University  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Soochow University  Changzhou China"},{"name":"Department of Pharmacy The First People's Hospital of Changzhou  Changzhou 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