{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:30:25Z","timestamp":1787121025724,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010acting intramuscular cabotegravir plus rilpivirine (LA\u2010CAB\u2009+\u2009RPV) is an effective maintenance antiretroviral regimen for virologically suppressed people with HIV. However, its use in individuals receiving chronic anticoagulation is limited by concerns regarding intramuscular bleeding risk, and real\u2010world data are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an observational, prospective, single\u2010centre cohort study including all people with HIV (PVIH) who initiated LA\u2010CAB\u2009+\u2009RPV at Hospital Cl\u00ednic of Barcelona since February 2023 until April 2026. Patients receiving chronic anticoagulation during the follow\u2010up were identified and assessed for safety and virological outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 964 PVIH who started LA\u2010CAB\u2009+\u2009RPV in our cohort, three were identified who received concomitantly chronic anticoagulation (direct oral anticoagulants or low\u2010molecular\u2010weight heparin). They received injections using standard deep intramuscular technique with post\u2010injection compression. No clinically relevant injection\u2010site hematomas or haemorrhagic complications were observed. Viral suppression was maintained in all cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This real\u2010world case series suggest that chronic anticoagulant therapy alone should not automatically preclude the use of LA\u2010CAB\u2009+\u2009RPV. With careful patient selection and appropriate injection techniques, LA\u2010CAB\u2009+\u2009RPV may represent a safe and effective treatment option for selected people with HIV receiving anticoagulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70771","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:15:11Z","timestamp":1787120111000},"source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010acting cabotegravir and rilpivirine in people with HIV receiving chronic anticoagulation: A real\u2010world case series"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-6352","authenticated-orcid":false,"given":"Montserrat","family":"Laguno","sequence":"first","affiliation":[{"name":"HIV Unit, Infectious Diseases Service Hospital Cl\u00ednic Barcelona\u2010Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-4726","authenticated-orcid":false,"given":"Berta","family":"Torres","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service Hospital Cl\u00ednic Barcelona\u2010Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-4101","authenticated-orcid":false,"given":"Maria","family":"Mart\u00ednez\u2010Rebollar","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious 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