{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:16:41Z","timestamp":1787991401092,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug\u2010metabolizing capacity are not routinely available. We evaluated the clinical relevance of pharmacogenomic (PGx) information for key pharmacogenes implicated in medication elimination in older adults presenting to the emergency department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen pharmacogenes were analysed using the Personal Medicine Profile\u2122 test. GeneYouIn PillCheck\u2122 software performed genotype\u2010to\u2010phenotype translations, identified drug\u2013gene interactions (DGIs) and generated a clinical decision report based on each patient's actual medication use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 125 acutely admitted older medical patients (median age 78.3\u2009years; 10 medications; 7 chronic diseases), PGx testing identified 88 DGIs across 63 patients (50.4%). Of these, 46.5% were considered by clinical experts to be clinically relevant for the individual patient, affecting 33 patients (26.4%) in the total study population. Frequently implicated pharmacogenes included\n                      <jats:italic>CYP2C19<\/jats:italic>\n                      (25.0%),\n                      <jats:italic>SLCO1B1<\/jats:italic>\n                      (25.0%),\n                      <jats:italic>CYP2D6<\/jats:italic>\n                      (20.5%),\n                      <jats:italic>CYP2C9<\/jats:italic>\n                      (14.8%) and\n                      <jats:italic>OPRM1<\/jats:italic>\n                      (6.8%), and frequently implicated medications included losartan (13.6%), pantoprazole (12.5%), simvastatin (12.5%), atorvastatin (11.4%) and metoprolol (11.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With more than one\u2010quarter of acutely admitted older medical patients having one or more clinically relevant DGIs, these findings suggest that PGx information may have meaningful clinical utility for improving prescribing practices in acute care. However, interpretation in this population requires careful consideration of other factors such as nutritional status and inflammation that may modify pharmacogene activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70799","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:35:26Z","timestamp":1787988926000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8954-2675","authenticated-orcid":false,"given":"Louise Westberg Strejby","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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