{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:07:58Z","timestamp":1788739678615,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["TMU113\u2010AE1\u2010B06"],"award-info":[{"award-number":["TMU113\u2010AE1\u2010B06"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidermal growth factor receptor\u2013tyrosine kinase inhibitors (EGFR\u2010TKIs) have substantially improved outcomes in non\u2010small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association between concomitant prescriptions of H1\u2010antihistamines (H1AHs) and clinical outcomes in NSCLC patients undergoing EGFR\u2010TKIs therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using the Taipei Medical University Clinical Research Database (TMUCRD) linked to the Taiwan Cancer Registry. Patients with advanced NSCLC receiving EGFR\u2010TKI therapy between 1 January 2008 and 31 December 2022 were classified according to concomitant prescription of H1AHs. The primary and secondary endpoints were time to treatment failure (TTF) and all\u2010cause mortality, respectively. Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. Sensitivity analyses and landmark analyses were performed to evaluate the robustness of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 828 eligible patients, 475 (57.37%) received concomitant H1AHs during EGFR\u2010TKIs therapy, whereas 353 (42.63%) did not. Concomitant prescriptions of H1AHs exhibited a significantly reduced risk of treatment failure (aHR; 0.61, 95% CI; 0.53\u20130.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), corresponding to longer mean TTF (2.09\n                      <jats:italic>vs<\/jats:italic>\n                      . 1.25\u2009years), as well as a lower risk of all\u2010cause mortality (aHR; 0.36, 95% CI; 0.30\u20130.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). A stronger association was observed in patients with extended durations of H1AHs exposure (\u226560 or \u226590\u2009days).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Concomitant prescriptions of H1AHs with EGFR\u2010TKIs therapy were associated with a significantly reduced risk of treatment failure and mortality in patients with advanced NSCLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70812","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T23:25:17Z","timestamp":1788737117000},"source":"Crossref","is-referenced-by-count":0,"title":["The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR\u2010TKIs treatment"],"prefix":"10.1002","author":[{"given":"Van Thuan","family":"Nguyen","sequence":"first","affiliation":[{"name":"International PhD Program in Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Hoan My Academy Hoan My Medical Corporation  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Hoang","family":"Le","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhu Quynh","family":"Phan","sequence":"additional","affiliation":[{"name":"International PhD Program in Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Infection Control Cho Ray Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toan Trung","family":"Duong","sequence":"additional","affiliation":[{"name":"International PhD Program in Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi Anh","family":"Thu","sequence":"additional","affiliation":[{"name":"Hoan My Academy Hoan My Medical Corporation  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Chia","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Big Data Research Center, Taipei Medical University Hospital Taipei Medical University  Taipei Taiwan"},{"name":"International Center for Health Information Technology, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Big Data Research Center, Taipei Medical University Hospital Taipei Medical University  Taipei Taiwan"},{"name":"International Center for Health Information Technology, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Huei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Office of Data Science Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Data Science, College of Management Taipei Medical University  Taipei City Taiwan"},{"name":"Clinical Data Center, Office of Data Science Taipei Medical University  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2997-2404","authenticated-orcid":false,"given":"Jason C.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Clinical Big Data Research Center, Taipei Medical University Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Clinical Data Center, Office of Data Science Taipei Medical University  Taipei City Taiwan"},{"name":"Research Center of Health Care Industry Data Science, College of Management Taipei Medical University  Taipei Taiwan"},{"name":"International PhD Program in Biotech and Healthcare Management, College of Management Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Tien","family":"Su","sequence":"additional","affiliation":[{"name":"School of Public Health, College of Public Health Taipei Medical University  Taipei Taiwan"},{"name":"Department of Occupational Medicine Shuang Ho Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-9041","authenticated-orcid":false,"given":"Phung\u2010Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Clinical Big Data Research Center, Taipei Medical University Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Data 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