{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:50:43Z","timestamp":1791442243030,"version":"4.3.3"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:p>\n                    Beta\u2010adrenoreceptor blockers (beta\u2010blockers) and selective serotonin reuptake inhibitors (SSRIs) are commonly used medications and often used together, such as for the treatment of anxiety. However, there is no recent review of any potential adverse events related to concomitant use of medicines from each group. This scoping review therefore aimed to provide this narrative synthesis. Key databases were searched for articles published in English from 1 January 1990 to 24 November 2025 reporting any adverse event due to the concomitant use of beta\u2010blockers and SSRIs in people aged 18 or over. Any study design was permitted. From 2211 distinct records, 117 articles were eligible for full\u2010text screening, and 48 articles were included. Eight of these were review articles referring to otherwise\u2010included empirical studies. Most were interventional (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919, 36.9%) or case reports (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914, 29.2%). Bradycardia was the most frequently reported adverse event (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911) mostly in case reports involving metoprolol\u2013fluoxetine, metoprolol\u2013paroxetine, metoprolol\u2013sertraline or propranolol\u2013fluoxetine. Blood pressure changes (including hypotension)\u00a0were observed in half of studies which explored them. Neurocognitive\u2010related symptoms were heterogeneous and there were four case reports\/series of self\u2010poisoning suicide or self\u2010harm. The adverse events discussed in this review could be signals for drug\u2013drug interactions. Where mechanism was postulated, authors mostly proposed pharmacokinetically mediated effects via Cytochrome P450 2D6. Signals described in this review of potential adverse events should be examined in robust observational studies of specific beta\u2010blocker\u2013SSRI combinations. This will enable precise estimation of the magnitude of any associated risks and provide insight into the potential mechanism.\n                  <\/jats:p>","DOI":"10.1002\/bcp.70850","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:10:00Z","timestamp":1791439800000},"source":"Crossref","is-referenced-by-count":0,"title":["A scoping review of adverse events associated with concomitant beta\u2010adrenoreceptor blockers and selective serotonin reuptake inhibitors"],"prefix":"10.1002","author":[{"given":"Ziyi","family":"Cai","sequence":"first","affiliation":[{"name":"Aston Centre of Excellence for Pharmacotherapy Optimisation and Pharmacoepidemiology Research, Aston Pharmacy School Aston University  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sutton","sequence":"additional","affiliation":[{"name":"Aston Centre of Excellence for Pharmacotherapy Optimisation and Pharmacoepidemiology Research, Aston Pharmacy School Aston University  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Archer","sequence":"additional","affiliation":[{"name":"Centre for Academic Primary Care (CAPC), Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-1402","authenticated-orcid":false,"given":"Caroline S.","family":"Copeland","sequence":"additional","affiliation":[{"name":"National Programme on Substance Use Mortality  London UK"},{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hayes","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"},{"name":"Camden and Islington NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Lidbetter","sequence":"additional","affiliation":[{"name":"Anxiety UK  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth K. 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