{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:42Z","timestamp":1792831062881,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Careful consideration of drug\u2013drug interactions (DDIs) is critical as people with HIV age. We analysed queries submitted to the University of Liverpool HIV Drug Interactions Database to assess changes in prescribing patterns over 5\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Queries submitted between January 2020 and December 2024 were extracted and categorized by year, antiretroviral agent, comedication class, interaction severity (green\/yellow\/amber\/red) and country. Descriptive statistics and annual trends were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 7\u2009274\u2009301 queries from 48 countries were recorded, representing a 441% increase over the study period. Dolutegravir (21%) and bictegravir (20%) were the most queried antiretrovirals, and queries involving unboosted integrase inhibitors rose. The most queried comedication classes were antibacterials, lipid\u2010lowering agents and supplements\/vitamins. Amber and red DDIs declined by 6% and 3% between January 2020 and December 2024, while green increased by 9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Query volume rose markedly while DDI severity declined, likely reflecting broader use of modern antiretrovirals with more favourable interaction profiles. Continued vigilance and interaction\u2010checking tools remain essential in HIV care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70872","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:11:26Z","timestamp":1792829486000},"source":"Crossref","is-referenced-by-count":0,"title":["Analysis of queries in an HIV drug\u2013drug interaction checker to explore changes in prescribing patterns: A 5\u2010year analysis"],"prefix":"10.1002","author":[{"given":"Cecile","family":"Gras","sequence":"first","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Bichat\u2010Claude Bernard, Service de Pharmacologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh P.","family":"Le","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Bichat\u2010Claude Bernard, Service de Pharmacologie  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, IAME  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Chiong","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Seddon","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-7050","authenticated-orcid":false,"given":"Catia","family":"Marzolini","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics University of Liverpool  Liverpool UK"},{"name":"Service and Laboratory of Clinical Pharmacology, Department of Laboratory Medicine and Pathology University Hospital Lausanne and University of Lausanne  Lausanne Switzerland"},{"name":"Division of Infectious Diseases University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saye","family":"Khoo","sequence":"additional","affiliation":[{"name":"Centre for Experimental Therapeutics University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(23)00028\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae557"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003122"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25449"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003226"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.70120"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70229"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010021\u201001005\u20101"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2024.2415295"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz811"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15614"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa918"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1393"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.7970"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.2006.02809.x"}],"container-title":["British 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