{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:49:52Z","timestamp":1791442192983,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Clin Pharmacol"],"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to develop a structured list of value assessment criteria for drug repurposing (DR) projects designed to support consistent, evidence\u2010informed decision\u2010making by funders. The assessment criteria were developed within the REMEDi4ALL project, a multi\u2010stakeholder Horizon Europe funded initiative to advance DR and were validated through consultation with public and philanthropic funding organizations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant assessment criteria were identified through a review of organizational documents and stakeholder consultations and were further supplemented by a targeted literature search in PubMed and Google Scholar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 330 candidate criteria were identified from funder documentation and peer\u2010reviewed literature. Following internal review and consultation with additional REMEDi4ALL partner organizations, 37 assessment criteria were defined and organized into five domains: basic enablers, expected benefits, technical implementation, business opportunity and fundraising profile. Each criterion was assigned a clear, standardized definition to ensure consistent interpretation and application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents a transparent, adaptable and non\u2010proprietary set of value assessment criteria to support the evaluation of DR proposals. It addresses key methodological and applicability gaps by enabling funders to apply structured assessments that reflect diverse value perspectives and stages of development in standalone or joint funding settings. The criteria list is clearly defined and grouped into five domains that also serves as the core for further application. The list has already been implemented in an Excel\u2010based application to select, weight and score items based on funder's strategic priorities and project maturity. It is freely available through the REMEDi4ALL platform.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bcp.70875","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:57:15Z","timestamp":1791439035000},"source":"Crossref","is-referenced-by-count":0,"title":["Defining a comprehensive set of value assessment criteria for funders of drug repurposing initiatives"],"prefix":"10.1002","author":[{"given":"Dalma","family":"Hossz\u00fa","sequence":"first","affiliation":[{"name":"Syreon Research Institute  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1599-3124","authenticated-orcid":false,"given":"Krist\u00f3f","family":"Gy\u00f6ngy\u00f6si","sequence":"additional","affiliation":[{"name":"Syreon Research Institute  Budapest Hungary"},{"name":"Center for Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"},{"name":"Center for Health Technology Assessment Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Per\u00e9nyi","sequence":"additional","affiliation":[{"name":"Syreon Research Institute  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene G.","family":"van der Meer","sequence":"additional","affiliation":[{"name":"ZonMw  The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunja","family":"Huijbers","sequence":"additional","affiliation":[{"name":"ZonMw  The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Pantziarka","sequence":"additional","affiliation":[{"name":"Anticancer Fund  Meise Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Inotai","sequence":"additional","affiliation":[{"name":"Syreon Research Institute  Budapest Hungary"},{"name":"Center for Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"},{"name":"Center for Health Technology Assessment Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Lo","sequence":"additional","affiliation":[{"name":"European Infrastructure for Translational Medicine (EATRIS)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Thompson","sequence":"additional","affiliation":[{"name":"Beacon for Rare Diseases  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Kal\u00f3","sequence":"additional","affiliation":[{"name":"Syreon Research Institute  Budapest Hungary"},{"name":"Center for Pharmacology and Drug Research &amp; Development Semmelweis University  Budapest Hungary"},{"name":"Center for Health Technology Assessment Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcell","family":"Csan\u00e1di","sequence":"additional","affiliation":[{"name":"Syreon Research Institute  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/534314a"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1387517"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010022\u201006713\u2010y"},{"key":"e_1_2_8_6_1","unstructured":"RSNN ZonMw Stimulating drug repurposing: regulatory legal and financial opportunities to improve patient access Regulatory Science Network Netherlands 2024 retrieved October 13 2025 https:\/\/www.rsnn.nl\/sites\/rsnn\/files\/2024\u201002\/RPP%20\u2010%20Stimulating%20Drug%20Repurposing.pdf"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70243"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/20016689.2017.1264717"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12962\u2010021\u201000311\u20106"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010021\u201005273\u2010x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2701"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1166"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddstr.2011.10.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010022\u201008272\u2010z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.746987"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010023\u201002753\u2010y"},{"key":"e_1_2_8_17_1","unstructured":"REMEDi4ALL A practical guide to creating joint funding calls for impactful drug repurposing research 2024 retrieved https:\/\/remedi4all.org\/wp-content\/uploads\/2024\/09\/R4All-D9.2-Guide-to-Creating-Joint-Funding-Calls-for-Impactful-DR-Research.pdf"},{"key":"e_1_2_8_18_1","unstructured":"REMEDi4ALL Glossary abbreviations and acronyms 2024 retrieved October 13 2025 https:\/\/remedi4all.org\/glossary-abbreviations-and-acronyms\/"},{"key":"e_1_2_8_19_1","unstructured":"Hossz\u00faDP\u00e1lfiMPetyk\u00f3Zset al.In\u2010depth exploration of assessment criteria for funding organizations involved in drug repurposing (INT11) 2024 retrieved October 13 2025 https:\/\/remedi4all.org\/wp\u2010content\/uploads\/2024\/04\/INT11_In\u2010depth\u2010exploration\u2010of\u2010assessment\u2010criteria\u2010for\u2010funding\u2010organizations\u2010involved\u2010in\u2010drug\u2010repurposing.pdf"},{"key":"e_1_2_8_20_1","unstructured":"REMEDi4ALL Framework for judging the project value of repurposed medicines 2024 retrieved October 13 2025 https:\/\/remedi4all.org\/framework-for-judging-the-project-value-of-repurposed-medicines\/"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respol.2003.10.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2018.1508345"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106963\u201012\u2010332"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bcp.70875","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bcp.70875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:57:17Z","timestamp":1791439037000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/bcp.70875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":23,"alternative-id":["10.1002\/bcp.70875"],"URL":"https:\/\/doi.org\/10.1002\/bcp.70875","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"article-number":"bcp.70875"}}