{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T21:01:21Z","timestamp":1761339681315,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["24590053"],"award-info":[{"award-number":["24590053"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the effect of epinephrine (a vasoconstrictor) and hydralazine (a vasodilator) on the hepatic disposition of 5\u2010fluorouracil (5\u2010FU) after application to the surface of the liver in rats. Normal livers were compared with a Walker 256 carcinoma cell tumor model. A cylindrical diffusion cell was attached to the liver surface. 5\u2010Fluorouracil was added into the diffusion cell in combination with vasomodulators or after pretreatment with epinephrine. After selected treatment times, the 5\u2010FU concentrations were assayed at three sites in the excised livers. The 5\u2010FU concentration in the region under the cell attachment site (site 1) was significantly higher after concomitant application of 5\u2010FU and epinephrine, compared with 5\u2010FU alone, and increased in an epinephrine dose\u2010dependent manner. On the other hand, preferential distribution of 5\u2010FU at site 1 was not seen when applied in combination with hydralazine. After 10\u00a0min of epinephrine pretreatment, the concentration of 5\u2010FU at site 1 was approximately two times higher than that for the control. Furthermore, the 5\u2010FU concentration at site 1 of the tumor model was greatly increased compared with the normal liver. These results suggest that application of epinephrine to the liver surface might enhance the accumulation of 5\u2010FU at the desired target site.<\/jats:p>","DOI":"10.1002\/bdd.2073","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T09:52:42Z","timestamp":1488189162000},"page":"367-372","source":"Crossref","is-referenced-by-count":3,"title":["Influence of vasomodulators and tumor transplantation on the disposition of 5\u2010fluorouracil after application to the liver surface in rats"],"prefix":"10.1002","volume":"38","author":[{"given":"Yukinobu","family":"Kodama","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Graduate School of Biomedical Sciences Nagasaki University  1\u20107\u20101 Sakamoto Nagasaki 852\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Horishita","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Graduate School of Biomedical 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