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Before curcumin\/dextrin complex (CDC), a potent antioxidant and anti\u2010inflammatory agent, can be used clinically we need to better understand the intracellular uptake under hypothermic conditions on a rat model of liver donation after circulatory death (DCD) and brain death (DBD). To be able to use the fluorescence of CDC for quantification the stability of CDC in different preservation solutions at 4\u00b0C or 37\u00b0C was investigated. Livers from Wistar rats were procured after being flushed\u2010out through the portal vein using CDC\u2010enriched preservation solutions and stored at 4\u00b0C for variable periods. The CDC signal was stable in different preservation solutions over a period of 4\u00a0h and allowed the rapid and lasting uptake of curcumin into cells. After 4\u00a0h of preservation, CDC was no longer visible microscopically, and HPLC analysis showed very low to non\u2010detectable tissue levels of CDC, proving metabolization during preservation. However, the distribution of CDC was not affected by warm ischemia damage (p\u00a0=\u00a00.278) nor by flushing the livers before or after 4\u00a0h of cold storage and without a warm preflush. Finally, curcumin reduced oxidative stress, lowered histological injury and did not change gene expression after WI\/cold storage. Therefore, the use of CDC flush solution for the initial organ flush can offer a promising approach to the enhancement of liver preservation and the maintenance of its quality.<\/jats:p>","DOI":"10.1002\/bdd.2108","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T13:22:37Z","timestamp":1507036957000},"page":"18-29","source":"Crossref","is-referenced-by-count":8,"title":["Hepatocellular uptake of cyclodextrin\u2010complexed curcumin during liver preservation: A feasibility study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-7968","authenticated-orcid":false,"given":"Saber Abdelkader","family":"Saidi","sequence":"first","affiliation":[{"name":"Liver Research Facility, Laboratory of Hepatology, Faculty of Medicine University Hospital Gasthuisberg  Leuven Belgium"},{"name":"Laboratory of Animal Ecophysiology\/Department of Life Sciences  Sfax Tunisia"},{"name":"Faculty of Science and Arts\u2010Khulais Jeddah University  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Meurisse","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery and Transplantation  CHU Liege, B4000 Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Jochmans","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplantation Surgery University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Microbiology and Immunology KU Leuven \u2010 University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Heedfeld","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplantation Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Wylin","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplantation Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Parkkinen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine\/Biochemistry University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplantation Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diethard","family":"Monbaliu","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplantation Surgery University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelfattah","family":"El Feki","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Ecophysiology\/Department of Life Sciences  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"van Pelt","sequence":"additional","affiliation":[{"name":"Liver Research Facility, Laboratory of Hepatology, Faculty of Medicine University Hospital Gasthuisberg  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22117"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.09.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.03.073"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50105"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.12.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000232674.52951.ff"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(12)60194-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i33.4491"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(93)90307-P"},{"key":"e_1_2_6_13_1","first-page":"81","article-title":"Chemistry and biochemistry of 4\u2010hydroxynonenal, malonaldehyde and related aldehydes. 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