{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:20:40Z","timestamp":1779081640339,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","award":["2019R1A6C1010001"],"award-info":[{"award-number":["2019R1A6C1010001"]}],"id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","award":["316017\u20103"],"award-info":[{"award-number":["316017\u20103"]}],"id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ginseng (<jats:italic>Panax ginseng<\/jats:italic> Meyer) is a popular traditional herbal medicine used worldwide. Patients often take ginseng preparations with other medicines where the ginseng dose could exceed the recommended dose during long\u2010term administration. However, ginseng\u2013drug interactions at high doses of ginseng are poorly understood. This study showed the possibility of herb\u2013drug interactions between the Korean red ginseng (KRG) extract and cytochrome P450 (CYP) substrates in higher administration in mice. The CYP activities were determined in vivo after oral administration of KRG extract doses of 0.5, 1.0, and 2.0 g\/kg for 2 or 4 weeks by monitoring the concentration of five CYP substrates\/metabolites in the blood. The area under the curve for OH\u2010midazolam\/midazolam catalysed by CYP3A was increased significantly by the administration of 2.0 g\/kg KRG extract for 2 and 4 weeks. CYP3A\u2010catalysed midazolam 1\u02b9\u2010hydroxylation also increased significantly in a dose\u2010 and time\u2010dependent manner in the S9 fraction of mouse liver which was not related to induction by transcription. Whereas CYP2D\u2010catalysed dextromethorphan <jats:italic>O<\/jats:italic>\u2010deethylation decreased in a dose\u2010 and time\u2010dependent manner in vivo. In conclusion, interactions were observed between KRG extract and CYP2D and CYP3A substrates at subchronic\u2013high doses of KRG administration in mice.<\/jats:p>","DOI":"10.1002\/bdd.2246","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T19:08:45Z","timestamp":1592507325000},"page":"295-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of red ginseng\u2013drug interaction by CYP3A activity increased in high dose administration in mice"],"prefix":"10.1002","volume":"41","author":[{"given":"Younah","family":"Kim","sequence":"first","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Jae","family":"Jo","sequence":"additional","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piljoung","family":"Cho","sequence":"additional","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riya","family":"Shrestha","sequence":"additional","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Min","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chosun University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hwan","family":"Ki","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chosun University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Sik","family":"Song","sequence":"additional","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Hyeon","family":"Liu","sequence":"additional","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Im\u2010Sook","family":"Song","sequence":"additional","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Yeungnam University Gyeongsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Mok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-701X","authenticated-orcid":false,"given":"Sangkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"BK21 Plus KNU Multi\u2010Omics based Creative Drug Research Team College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/011542650502000133"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01469.x"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02878.x"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.05.015"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bms148"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.07.006"},{"key":"e_1_2_7_1_8_1","first-page":"41","article-title":"Simultaneous quantification of 13 ginsenosides by LC\u2010MS\/MS and its application in diverse ginseng extracts","volume":"9","author":"Jo J. J.","year":"2018","journal-title":"Mass Spectrometry Letters"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-018-1012-8"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.5478\/MSL.2016.7.4.106"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2012.36.4.354"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.11.005"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.5352\/JLS.2012.22.8.991"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.11.002"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.32.5.512"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.04.009"},{"key":"e_1_2_7_1_17_1","first-page":"508","article-title":"Single\u2010 and repeated\u2010dose toxicities of Korean red ginseng extract in mice","volume":"4","author":"Lim S. H.","year":"2005","journal-title":"The Annual Report of KNTP"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.07.004"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1500"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130155097"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11203-7"},{"key":"e_1_2_7_1_22_1","first-page":"618","article-title":"Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms","volume":"292","author":"Perloff M. D.","year":"2000","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-016-0387-5"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19022588"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.17480\/psk.2015.59.2.49"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2012.689888"},{"key":"e_1_2_7_1_27_1","first-page":"56","article-title":"Herbal supplement sales in US increase 7.7% in 2016","volume":"115","author":"Smith T.","year":"2017","journal-title":"American Botanical Council"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2018.05.002"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.8.1065"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.4172\/2167-0943.1000106"},{"issue":"3","key":"e_1_2_7_1_31_1","first-page":"1024","article-title":"Effects of age on in vitro midazolam biotransformation in male CD\u20101 mouse liver microsomes","volume":"292","author":"Warrington J. S.","year":"2000","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.001917"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.11.012"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.12.007"},{"key":"e_1_2_7_1_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00201"},{"key":"e_1_2_7_1_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmz004"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.2246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.2246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdd.2246","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.2246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:00:22Z","timestamp":1693933222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.2246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/bdd.2246"],"URL":"https:\/\/doi.org\/10.1002\/bdd.2246","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2019-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}