{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:33:30Z","timestamp":1747146810465,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002532","name":"Kyungsung University","doi-asserted-by":"publisher","award":["2019093"],"award-info":[{"award-number":["2019093"]}],"id":[{"id":"10.13039\/501100002532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102018R1D1A1B07048150"],"award-info":[{"award-number":["NRF\u20102018R1D1A1B07048150"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rebamipide is used widely in East Asia for the treatment of gastric ulcers, acute gastritis, and exacerbated chronic gastritis. The objective of this study was to investigate the pharmacokinetic (PK) properties of rebamipide following single oral administration in rats and dogs. Eleven rats and dogs received single oral administrations of rebamipide (35 mg\/kg and 100 mg, respectively). Blood samples were collected according to the assigned schedule, and the plasma concentration of rebamipide was determined using liquid chromatography\u2013tandem mass spectrometry. A double\u2010peak phenomenon was observed in the PK profile of rebamipide in rats. In contrast, rebamipide showed a conventional PK profile without double peaks in dogs. The half\u2010life of rebamipide in rats (12.85 \u00b1 7.86 h) was longer than that in dogs (5.62 \u00b1 2.24 h), and the apparent total clearance (Cl<jats:sub>t<\/jats:sub>\/F) of rebamipide in rats (3.32 \u00b1 1.18 L\/h) was lower than that in dogs (105.01 \u00b1 42.37 L\/h). Simple allometric approaches showed that the correlation between body weight and Cl<jats:sub>t<\/jats:sub>\/F (R<jats:sup>2<\/jats:sup> = 0.9287) among rats, dogs, and humans appeared satisfactory. This finding will help not only in understanding the pharmacology of rebamipide but also in establishing a strategy for in vivo evaluation of novel rebamipide formulations.<\/jats:p>","DOI":"10.1002\/bdd.2247","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T18:34:23Z","timestamp":1592505263000},"page":"268-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interspecies differences on pharmacokinetics of rebamipide following oral administration to rats and dogs"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-0565","authenticated-orcid":false,"given":"In\u2010hwan","family":"Baek","sequence":"first","affiliation":[{"name":"College of Pharmacy Kyungsung University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Kyoung","family":"Ha","sequence":"additional","affiliation":[{"name":"College of Pharmacy Kyungsung University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010seul","family":"Joo","sequence":"additional","affiliation":[{"name":"College of Pharmacy Kyungsung University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy Kyungsung University  Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"issue":"9","key":"e_1_2_8_1_2_1","first-page":"5S","article-title":"Rebamipide: Overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing","volume":"43","author":"Arakawa T.","year":"1998","journal-title":"Digestive Diseases and Sciences"},{"issue":"2","key":"e_1_2_8_1_3_1","first-page":"150","article-title":"Comparative study of first\u2010in\u2010human dose estimation approaches using pharmacometrics","volume":"26","author":"Baek I. 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