{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:01:30Z","timestamp":1760061690583},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,4,10]],"date-time":"2001-04-10T00:00:00Z","timestamp":986860800000},"content-version":"vor","delay-in-days":221,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potential for a pharmacokinetic interaction between naproxen and diphenhydramine was examined in a randomized three\u2010way crossover design with a 1\u2010week washout between dosing. Single oral doses of 220 mg of naproxen sodium and 50 mg of diphenhydramine hydrochloride were given separately and together to 30 healthy male and female subjects. Heparinized blood samples obtained for 48 h postdose were assayed for plasma naproxen and diphenhydramine concentrations using validated high\u2010performance liquid chromatography (HPLC) and gas chromatography (GC) assay methods, respectively. The area under the plasma concentration\u2013time curve (AUC), maximum plasma concentrations (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>), time of <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> (<jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>) and terminal exponential half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>1\/2,<jats:italic>z<\/jats:italic><\/jats:sub>), were analysed for significant treatment differences by analysis of variance (ANOVA). Based on absence of significant treatment effects on AUC and <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>, single\u2010dose oral co\u2010administration of 220 mg of naproxen sodium with 50 mg of diphenhydramine hydrochloride does not alter the pharmacokinetics of either naproxen or diphenhydramine. Significant treatment differences seen for naproxen <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> (0.3 h, males only) and diphenhydramine <jats:italic>t<\/jats:italic><jats:sub>1\/2,<jats:italic>z<\/jats:italic><\/jats:sub> (0.8 h, females only) were minor and are unlikely to have therapeutic consequences. Thus, efficacy and safety of concomitant naproxen and diphenhydramine should not be altered due to a pharmacokinetic interaction. Copyright \u00a9 2000 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bdd.234","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:21:39Z","timestamp":1030306899000},"page":"229-233","source":"Crossref","is-referenced-by-count":10,"title":["Absence of pharmacokinetic interaction between orally co\u2010administered naproxen sodium and diphenhydramine hydrochloride"],"prefix":"10.1002","volume":"21","author":[{"given":"R.D.","family":"Toothaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Gillen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Helsinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Kindberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.L.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1980.tb01753.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.20.1457"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-081X(199605)17:4<355::AID-BDD960>3.0.CO;2-N"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb02454.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1986.tb02946.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01067905"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03258420"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90155-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1978246706"},{"key":"e_1_2_1_11_2","first-page":"597","article-title":"The effects of cimetidine, ranitidine and famotidine on the single\u2010dose pharmacokinetics of naproxen and its metabolites in humans","volume":"31","author":"Vree TB","year":"1993","journal-title":"Int J Clin Pharmacol"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.234","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:32:10Z","timestamp":1698575530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["10.1002\/bdd.234"],"URL":"https:\/\/doi.org\/10.1002\/bdd.234","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}