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Tetrahydrocurcumin (THC) is one of the major reductive metabolites of curcumin. A pharmacokinetic study using ultra\u2010high\u2010performance liquid chromatography\u2010tandem mass spectrometry (UHPLC\u2010MS\/MS) for the simultaneous determination of curcumin, THC, quercetin (QR), and paeoniflorin (PF) in rat plasma had been performed. In this study, the regional distributions of curcumin and tetrahydrocurcumin in the liver and the three segments of small intestine (duodenum, jejunum, and ileum) of rats when orally co\u2010administered with quercetin and paeoniflorin were carried out. Drug concentrations were determined using UHPLC\u2010MS\/MS. The results showed that curcumin was well distributed in the small intestine, while the distributions of tetrahydrocurcumin in the liver, duodenum, jejunum were similar, but much more abundant in the ileum. When orally co\u2010administered with quercetin and paeoniflorin, the tissue to plasma concentration ratios (K<jats:sub>p<\/jats:sub> values) of curcumin in the three segments of the small intestine were increased, indicating that the presence of quercetin and paeoniflorin increases the distribution of curcumin in these regions. Moreover, the half\u2010life (t<jats:sub>1\/2<\/jats:sub>) of THC in the liver was significantly prolonged, and the K<jats:sub>p<\/jats:sub> value of THC in the liver was increased and the K<jats:sub>p<\/jats:sub> values in the small intestine were decreased, suggesting that the combination of quercetin and paeoniflorin might suppress the metabolism of curcumin in the small intestine. In brief, the combination had an effect on the distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats.<\/jats:p>","DOI":"10.1002\/bdd.2346","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T00:13:54Z","timestamp":1673655234000},"page":"183-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regional distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats when orally co\u2010administered with quercetin and paeoniflorin"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-7303","authenticated-orcid":false,"given":"Weilan","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangzhou Chest Hospital  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dake","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biaochang","family":"Lao","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Hospital of South China University of Technology  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology School of Pharmaceutical Sciences Sun Yat\u2010sen University  Guangzhou Guangdong Province China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20010185"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057112444927"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.08.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010011\u20100411\u2010x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/879676"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102426"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016217108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0024\u20103205(02)02235\u2010x"},{"key":"e_1_2_9_11_1","first-page":"105","article-title":"Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine","volume":"11","author":"Ireson C. 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