{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:00:50Z","timestamp":1759384850668},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,13]],"date-time":"2006-01-13T00:00:00Z","timestamp":1137110400000},"content-version":"vor","delay-in-days":9143,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The metabolism and pharmacokinetics of intravenously administered theophylline (100 mg) have been investigated in three healthy male volunteers who consumed 6 bottles day of a cola beverage, in addition to their usual intake of methylxanthines, for 7 days prior to and during the study. Five urinary metabolites were detected in addition to unchanged theophylline, that is 3\u2010methylxanthine, 1.3\u2010dimethyluric acid, 1\u2010methyluric acid, and two minor unknown metabolites. The elimination of theophylline, 1.3\u2010dimethyluric acid, 1\u2010methyluric acid, and the two unknowns was described by first\u2010order kinetics, whereas that of 3\u2010methylxanthine was described by Michaelis\u2010Menten kinetics. The results have been compared with those previously obtained in the same volunteers while consuming their usual intake of methylxanthine\u2010containing foods and beverages, and this shows that the addition of extra methylxanthines to the diet does not influence the disposition of theophylline. This is in marked contrast to the effect of deprivation of dietary methylxanthines on theophylline metabolism. The results are discussed in terms of the influence of methylxanthines on theophylline metabolism, and of its possible dose\u2010 dependency.<\/jats:p>","DOI":"10.1002\/bdd.2510020104","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T13:54:49Z","timestamp":1160834089000},"page":"31-37","source":"Crossref","is-referenced-by-count":14,"title":["The effect of increased caffeine intake on the metabolism and pharmacokinetics of theophylline in man"],"prefix":"10.1002","volume":"2","author":[{"given":"T. J.","family":"Monks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Lawrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197803040-00002"},{"key":"e_1_2_1_3_2","first-page":"173","volume":"21","author":"Caldwell J.","year":"1979","journal-title":"Pharmacologist"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1979264513"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)70714-X","volume":"228","author":"Cornish H. H.","year":"1957","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/03602537508993756"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1978.tb03717.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972132258"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1976.tb01528.x"},{"key":"e_1_2_1_10_2","unstructured":"T. J.Monks Ph.D. thesis. University of London (1978)."},{"key":"e_1_2_1_11_2","first-page":"121","volume-title":"Drug Metabolism from Microbe to Man","author":"Rowland M.","year":"1977"},{"key":"e_1_2_1_12_2","first-page":"27","volume-title":"Pharmacology and Pharmacokinelics","author":"Wagner J.","year":"1974"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.2510020104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.2510020104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T18:25:52Z","timestamp":1699727152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.2510020104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/bdd.2510020104"],"URL":"https:\/\/doi.org\/10.1002\/bdd.2510020104","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}