{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:53:15Z","timestamp":1764996795077},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":8776,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three indices of drug metabolism, antipyrine clearance <jats:italic>in vivo<\/jats:italic>, and aminopyrine N\u2010demethylase and bilirubin UDP\u2010glucuronyl transferase activity in liver biopsies, were studied in fifteen patients with amoebic liver abscess (with and without jaundice). The mean (\u00b1 S.E.) antipyrine half\u2010life in patients with jaundice was 21.64 (\u00b11.52)h and in patients without jaundice was 19.36 ( \u00b1 0.93)h. It was significantly prolonged in both groups of patients as compared to controls (11.63 \u00b1 0.86 h). It showed a good correlation with serum albumin (<jats:italic>p<\/jats:italic>&lt;0.01), prothrombin time index (<jats:italic>p<\/jats:italic>&lt;0.01), and aminopyrine N\u2010demethylase (<jats:italic>p<\/jats:italic>&lt;0.05). Aminopyrine N\u2010demethylase was found to be decreased in patients without jaundice but no significant change could be observed in patients with jaundice. Bilrubin UDP\u2010glucuronyl transferase showed no significant change in either of the groups.<\/jats:p>","DOI":"10.1002\/bdd.2510030106","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T14:06:23Z","timestamp":1160834783000},"page":"39-45","source":"Crossref","is-referenced-by-count":3,"title":["Antipyrine clearance, aminopyrine N\u2010demethylase, and bilirubin udp\u2010glucuronyl transferase activity in patients with amoebic liver abscess"],"prefix":"10.1002","volume":"3","author":[{"given":"A. P. S.","family":"Narang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. V.","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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