{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T10:40:14Z","timestamp":1699699214269},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":8503,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objectives of this study were to investigate the relationship between personality trait variables and theophylline disposition in asthmatic patients.<\/jats:p><jats:p>Twenty\u2010five patients admitted to a hospital who required intravenous theophylline for bronchodilation were studied. Data on theophylline half\u2010life, and the patients' histories on congestive heart failure, liver disease, and smoking behaviour were abstracted. Eysenck's personality inventory was administered to obtain a score on the two personality traits: neuroticism and extroversy.<\/jats:p><jats:p>High neurotic patients showed a significantly (<jats:italic>p<\/jats:italic>&lt; 0.005) lower theophylline half\u2010life. Neuroticism appeared to be, in this patient population, a more important determinant of theophylline half\u2010life than variables such as congestive heart failure, liver disease, or smoking behaviour.<\/jats:p>","DOI":"10.1002\/bdd.2510030404","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T14:18:11Z","timestamp":1160835491000},"page":"311-316","source":"Crossref","is-referenced-by-count":5,"title":["Personality traits and theophylline metabolism"],"prefix":"10.1002","volume":"3","author":[{"given":"Abraham G.","family":"Hartzema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sal","family":"Pancorbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1542\/peds.58.4.542","volume":"501","author":"Ellis E. F.","year":"1976","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_2","first-page":"229","volume":"118","author":"Powell J. R.","year":"1978","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_1_4_2","first-page":"1695","volume":"296","author":"Piafsky K. M.","year":"1978","journal-title":"N. Engl, J. Med."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1980.49"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01086153"},{"key":"e_1_2_1_7_2","volume-title":"Eysenck Personality Inventory","author":"Eysenck H. J.","year":"1968"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)81051-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197309202891202"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972133349"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.2510030404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.2510030404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T10:05:23Z","timestamp":1699697123000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.2510030404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,10]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,10]]}},"alternative-id":["10.1002\/bdd.2510030404"],"URL":"https:\/\/doi.org\/10.1002\/bdd.2510030404","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,10]]}}}