{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T10:06:56Z","timestamp":1751623616377},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":7195,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pharmacokinetics of cyanamide after 35 mg kg<jats:sup>\u22121<\/jats:sup> intravenous and oral administration to fasted and unfasted rats have been investigated. The plasma level are fitted well by a two\u2010compartment open model. The half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>\u03b2) of cyanamide in the rat was 1 hour and the plasma clearance (C1<jats:sub>p<\/jats:sub>) was 0.02 (1 kg<jats:sup>\u22121<\/jats:sup>) min<jats:sup>\u22121<\/jats:sup>. Food does not appear to modify the absolute bioavailability of cyanamide (<jats:italic>F<\/jats:italic> = 93.3 per cent fasted, <jats:italic>F<\/jats:italic> = 85.5 per cent unfasted), although it does retard drug absorption.<\/jats:p>","DOI":"10.1002\/bdd.2510070308","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T15:14:45Z","timestamp":1160838885000},"page":"273-280","source":"Crossref","is-referenced-by-count":4,"title":["Bioavailability of cyanamide in fasted and unfasted rats"],"prefix":"10.1002","volume":"7","author":[{"given":"R.","family":"Obach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Valles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Valles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Domenech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/cpt1979254454","volume":"26","author":"Brien J. F.","year":"1979","journal-title":"Clin. Pharmacol. Ther."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00607445"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(81)90018-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198427020-00004"},{"key":"e_1_2_1_6_2","unstructured":"R.Obach J.Domenech J.MorenoandJ. M.Pla\u2010Delfina Estudio preliminar de la farmacocin\u00e9tica de la cianamida en la rata. (Preliminary study of pharmacokinetics of cyanamide in rat) Communication to the First Spanish\u2010French Congress of Biopharmaceutics and Pharmacokinetics Barcelona Spain vol. 3 435."},{"key":"e_1_2_1_7_2","first-page":"367","volume-title":"Communication to the First European Congress of Biopharmaceutics and Pharmacokinetics","author":"Obach R.","year":"1981"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/03602538308991384"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1139\/y83-153"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac50153a027"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01117450"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1137\/0111030"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.2510070308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.2510070308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:14:22Z","timestamp":1697933662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.2510070308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1002\/bdd.2510070308"],"URL":"https:\/\/doi.org\/10.1002\/bdd.2510070308","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}