{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:23:54Z","timestamp":1770218634107,"version":"3.49.0"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T00:00:00Z","timestamp":1139356800000},"content-version":"vor","delay-in-days":6735,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An adaption of a published high performance liquid chromatographic (HPLC) assay for phenylpropanolamine (PPA) in plasma was used to examine PPA pharmacokinetics in dogs. Plasma was extracted into ethyl acetate after the addition of 3.5 per cent sodium carbonate, and was then back\u2010extracted into aqueous acetic acid. The acetic acid was injected onto a cyano column using a mobile phase of acetonitrile, dilute hydrochloric acid, and sodium heptane sulfonate. Detection was by UV absorbance at 210 nm. The relative standard deviation of replicate assays averaged 5.2 per cent over a concentration range of 50\u20101750 ng ml<jats:sup>\u22121<\/jats:sup> plasma. PPA extraction recovery exceeded 90 per cent. The limit of detection was 30 ng ml<jats:sup>\u22121<\/jats:sup> using 0.5 ml plasma and injecting 10\u03bc.<\/jats:p><jats:p>PPA disposition was characterized in three dogs administered PPA i.v. and orally in immediate\u2010release and controlled\u2010release formulations. The terminal elimination half\u2010life averaged 3.5 \u00b1 0.5 h after the i.v. dose. Oral absorption from the immediate\u2010release capsule was rapid and bioavailability was 98.2 \u00b1 6.9 per cent. PPA absorption from the controlled\u2010release dosage form was biphasic; an initial rapid phase was followed by a second, slower absorption phase which continued over 16 h. Plasma PPA concentrations then declined with a half\u2010life roughly parallel to the i.v. and oral immediate\u2010release half\u2010lives. Oral bioavailability from the controlled release tablet was 93.7 \u00b1 5.9 per cent.<\/jats:p>","DOI":"10.1002\/bdd.2510080509","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T11:16:49Z","timestamp":1160824609000},"page":"497-505","source":"Crossref","is-referenced-by-count":14,"title":["Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled\u2010release doses"],"prefix":"10.1002","volume":"8","author":[{"given":"Munir A.","family":"Hussain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce J.","family":"Aungst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Shefter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600500313"},{"key":"e_1_2_1_3_2","first-page":"153","volume":"220","author":"Thiercelin J. F.","year":"1976","journal-title":"Arch. Int. Pharmacodvn."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600720912"},{"key":"e_1_2_1_5_2","first-page":"39","volume":"22","author":"L\u00f6nnerholm G.","year":"1984","journal-title":"Int. J. Clin. Pharmacol. Ther. Toxicol."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600571122"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.2510080509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.2510080509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T11:47:59Z","timestamp":1697888879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.2510080509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,9]]}},"alternative-id":["10.1002\/bdd.2510080509"],"URL":"https:\/\/doi.org\/10.1002\/bdd.2510080509","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,9]]}}}