{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:27:13Z","timestamp":1759530433891},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":6038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arbaprostil is an orally active prostaglandin E<jats:sub>2<\/jats:sub> analogue. It has been developed as a drug to treat ulcers induced by non\u2010steroidal anti\u2010inflammatory drugs. In this study, pharmacokinetic interactions between arbaprostil and aspirin were examined in humans after chronic doses of both drugs. Subjects received either arbaprostil (50 \u03bcg), asprin (975 mg) or arbaprostil (50 \u03bcg) and aspirin (975 mg) four times a day for 6 days and one dose on 7th day. Blood and urine samples were collected after the last dose for 6 h. Pharmacokinetic parameters of arbaprostil, aspirin, and Salicylate were determined. Coadministration of arbaprostil significantly lowered the area under curve (5\u00b709 \u00b1 0\u00b732 \u03bcg hml<jats:sup>\u22121<\/jats:sup>vs 5\u00b778 \u00b1 0\u00b729 \u03bcg hml<jats:sup>\u22121<\/jats:sup>, mean \u00b1 SE, <jats:italic>p<\/jats:italic> &lt; 0\u00b705) and time (0\u00b745 \u00b1 0\u00b707 h vs 0\u00b770 \u00b1 0\u00b712 h, <jats:italic>p<\/jats:italic> &lt; 0\u00b705) to reach maximal plasma concentration of aspirin (acetylsalicylate). The pharmacokinetics of salicylate were not changed by arbaprostil, nor were the pharmacokinetics of arbaprostil affected by aspirin. Coadministration of these two drugs did not appear to potentiate the side\u2010effects of either drug. The results suggest that arbaprostil and aspirin may be administered together without clinically significant changes in pharmacokinetics or adverse side\u2010effects.<\/jats:p>","DOI":"10.1002\/bdd.2510100408","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T11:48:55Z","timestamp":1160826535000},"page":"411-422","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetic interactions between arbaprostil and aspirin in humans"],"prefix":"10.1002","volume":"10","author":[{"given":"Poe\u2010Hirr","family":"Hsyu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Pullen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winnie L.","family":"Gee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur R.","family":"Euler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"255","volume":"9","author":"Karim S. 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