{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:25:54Z","timestamp":1788819954727,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5764,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eight healthy volunteers received 50 mg of dimenhydrinate, a theoclate salt of diphenhydramine, orally, sublingually, and intravenously on three separate occasions in random sequence. Plasma diphenhydramine concentrations during 12 h after each dose were measured by gas\u2010liquid chromatography with nitrogen\u2010phosphorous detection. Mean peak plasma concentrations after sublingual administration were slightly lower than after oral dosage (38\u00b73 vs 47\u00b78 ng ml<jats:sup>\u22121<\/jats:sup>), and the time of peak concentration was similar (2\u00b76 vs 2\u00b73 h after dose). These differences did not reach statistical significance. The mean total area under the plasma concentration\u2010time curve (AUC) for sublingual administration was slightly but not significantly smaller than after oral dosage (221 vs 270 h ng ml<jats:sup>\u22121<\/jats:sup>). Systemic availability of diphenhydramine after sublingual dimenhydrinate, measured by the ratio of oral AUC to intravenous AUC, was slightly less than after oral dimenhydrinate (0\u00b758 vs 0\u00b769, NS), and both were significantly less than 1\u00b70. Thus sublingual and oral administration of dimenhydrinate result in comparable, but incomplete, systemic availability of diphenhydramine.<\/jats:p>","DOI":"10.1002\/bdd.2510110302","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T12:08:12Z","timestamp":1160827692000},"page":"185-189","source":"Crossref","is-referenced-by-count":21,"title":["Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration"],"prefix":"10.1002","volume":"11","author":[{"given":"Joseph M.","family":"Scavone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becki G.","family":"Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold S.","family":"Harmatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"von Moltke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Greenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900632"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197917060-00003"},{"key":"e_1_2_1_4_2","first-page":"1309","volume-title":"Martindale: The Extra Pharmacopoeia","author":"Reynolds J. 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