{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:19:14Z","timestamp":1700245154596},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T00:00:00Z","timestamp":1139356800000},"content-version":"vor","delay-in-days":4574,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of temporary water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of bumetanide were examined after intravenous (i.v.) administration of bumetanide, 8 mg kg<jats:sup>\u22121<\/jats:sup> to control and water deprived rats (<jats:italic>n<\/jats:italic> = 7). The values of AUC, <jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub> and MRT increased 79.0, 417, and 633 per cent, respectively, and CL and CL<jats:sub>NR<\/jats:sub> decreased 44.0 and 41.2 per cent, respectively, in water deprived rats. They were all significantly different. The decreased CL<jats:sub>NR<\/jats:sub> in water deprived rats could be due to decreased nonrenal metabolism of bumetanide; it could be supported that the amounts of glucuronide conjugate of bumetanide (52.5 vs 12.9 \u03bcg), desbutylbumetanide (170 vs 113 \u03bcg) and its glucuronide conjugation (191 vs 125 \u03bcg), and sum of the three metabolites (414 vs 229 \u03bcg), which are expressed in terms of bumetanide excreted in 24 h urine, decreased significantly in water deprived rats. The 8\u2010h urine outputs per 100 g body weight (4.32 vs 1.34 ml) also reduced significantly in water deprived rats, and it might be due to significantly reduced amounts of bumetanide excreted in 8 h urine (90.9 vs 25.7 \u03bcg) and\/or reduced kidney function in water deprived rats. The kidney function based on CL<jats:sub>lot<\/jats:sub> (9.87 vs 2.14 ml min<jats:sup>\u22121<\/jats:sup> kg<jats:sup>\u22121<\/jats:sup>) reduced significantly in water deprived rats. The 8\u2010h urinary excretions of sodium (0.430 vs 0.0818 mmol), potassium (0.567 vs 0.270 mmol), and chloride (0.549 vs 0.0624 mmol) per 100 g body weight also reduced significantly in water deprived rats.<\/jats:p>","DOI":"10.1002\/bdd.2510140602","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T09:10:59Z","timestamp":1160817059000},"page":"463-474","source":"Crossref","is-referenced-by-count":5,"title":["Effects of water deprivation on the pharmacokinetics and pharmacodynamics of bumetanide in rats"],"prefix":"10.1002","volume":"14","author":[{"given":"Ji Y.","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok N.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung G.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600720916"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1152\/ajplegacy.1970.219.6.1544","article-title":"Thermal dehydration of the rat: Distribution of losses among tissues","volume":"219","author":"Wallace W. 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