{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:23:42Z","timestamp":1778873022711,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":3847,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infectious excerbations of COPD are generally due to <jats:italic>Streptococcus pneumoniae, Haemophilus<\/jats:italic> speicies, and other Gram\u2010negative bacteria. Ofloxacin has potent activity against Gram\u2010negative species but is less effective against Gram\u2010positive species including <jats:italic>Streptococcus pneumoniae<\/jats:italic>. It has also been shown that the administration of ambroxol increases the concentration of some antibiotics in pulmonary tissues. The aim of the study was to determine whether ambroxol increases the bronchial tissue concentrations of ofloxacin to a level exceeding the MIC<jats:sub>90<\/jats:sub> of the bacterial species less susceptible to ofloxacin. 24 patients with COPD were randomized in two groups. Drug regimens of ofloxacin alone (200 mg twice daily) or ofloxacin (200 mg twice daily) + ambroxol (30 mg thrice daily) were administered over 10d. A fibroscopy was performed on day 10 with bronchial biopsies and broncho\u2010alveolar lavage. At steady state, concentrations of drug in plasma and bronchial samples were assayed by HPLC with fluorometric detection. There was no significant difference in the bronchial levels of ofloxacin between the two groups; however, in alveolar cells, ofloxacin concentration was three times higher in the group with ambroxol. Ambroxol does not increase ofloxacin concentrations in bronchial tissue because high concentrations are already present in the lung.<\/jats:p>","DOI":"10.1002\/bdd.2510160504","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T10:12:04Z","timestamp":1160820724000},"page":"393-401","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of the effects of ambroxol on the ofloxacin concentrations in bronchial tissues in COPD patients with infectious exacerbation"],"prefix":"10.1002","volume":"16","author":[{"given":"Fabrice","family":"Paganin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Bouvet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Chanez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Galtier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Godard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois B.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Bressolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/22.Supplement_C.9","article-title":"The comparative in vitro activity of ofloxacin","volume":"22","author":"Gr\u00fcneberg R. N.","year":"1988","journal-title":"J. Antimicrob Chemother."},{"issue":"146","key":"e_1_2_1_3_2","first-page":"585","article-title":"Quinolones antimicrobial agents in acute exacerbations of chronic bronchitis","volume":"69","author":"Maesen F. P. V.","year":"1986","journal-title":"Eur. J. Resp. Dis."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.97.2_Supplement.24S"},{"key":"e_1_2_1_5_2","first-page":"974","article-title":"Influence of ambroxol on the pulmonary level of antibiotics","volume":"31","author":"Wiemeyer J. 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