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Drug adherence was determined by quantitation of aluminum in stomach wall biopsies. Significantly more aluminum adhered to ulcer sites than to nearby nonulcer sites. Adherence of the complex did not significantly decrease from 1 to 4 h. The complexation of tetracycline to sucralfate did not alter the selective adherence of sucralfte to gastric ulcers, providing a mechanism of ulcer site\u2010selective drug delivery in the treatment of <jats:italic>Helicobacter pylori<\/jats:italic> gastric ulcer disease.<\/jats:p>","DOI":"10.1002\/bdd.2510160605","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T10:18:56Z","timestamp":1160821136000},"page":"475-479","source":"Crossref","is-referenced-by-count":14,"title":["Selective adherence of a sucralfate\u2014tetracycline complex to gastric ulcers: Implications for the treatment of <i>Helicobacter pylori<\/i>"],"prefix":"10.1002","volume":"16","author":[{"given":"Robert A","family":"Yokel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Dickey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur H.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104113241507"},{"key":"e_1_2_1_3_2","first-page":"34","article-title":"Helicobacter pylori and peptic ulcer disease","volume":"12","author":"Ateshkadi A.","year":"1993","journal-title":"Clin. 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