{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:05:55Z","timestamp":1778184355644,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T00:00:00Z","timestamp":1032480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Purpose<\/jats:italic>. To study the pharmacokinetics and dose proportionality of moxidectin in beagle dogs experimentally infected with the filarial parasite <jats:italic>Brugia pahangi<\/jats:italic>, and to evaluate and compare the results obtained from population pharmacokinetic analysis and individual compartmental analysis. <jats:italic>Method<\/jats:italic>. Thirty\u2010six infected dogs were selected and randomly allocated into six treatment groups of six dogs each. Doses of 250 or 1000\u03bcg\/kg were given orally. The plasma drug concentration\u2013time data were analyzed by population compartmental and individual compartmental methods. <jats:italic>Results<\/jats:italic>. The best pharmacokinetic model was a two\u2010compartment model with first\u2010order absorption. According to the results obtained from population compartmental analysis, moxidectin is a low clearance drug with a relatively high volume of distribution, resulting in a mean terminal half\u2010life of 458 h. Absorption was rapid with a mean absorption half\u2010life of 0.6 h and <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> of 2.75 h. Significant weight effect was found on Vc. These results were compared with results obtained from individual compartmental approach. A statistically significant (<jats:italic>p<\/jats:italic>&lt;0.01) gender difference in T1\/2\u03b2 was observed with the 250 \u03bcg\/kg dose, and a trend was observed with a greater T1\/2\u03b2 in females at the 1000\u03bcg\/kg dose. No gender effect on other pharmacokinetic parameters was found. <jats:italic>Conclusions<\/jats:italic>. A pronounced distribution phase was observed and there was a significant weight effect on Vc. Dose proportionality of moxidectin was assessed by comparing the AUC (0\u2010last determination) values for 250 and 1000\u03bcg\/kg. The pharmacokinetics are independent of dose over this dose range. 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