{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:56:28Z","timestamp":1760061388495},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,8,29]],"date-time":"2002-08-29T00:00:00Z","timestamp":1030579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The contribution of an entero\u2010salivary recirculation (salivary secretion\u2014swallowed\u2014reabsorption of drug from the gastrointestinal tract) to the values of the pharmacokinetic parameters of paracetamol was studied in a two\u2010way crossover design. Five healthy volunteers took a tablet of Paracetamol (500 mg) in two occasions separated by a washout period. The difference between the two treatments consisted of saliva that was allowed or not to be swallowed during the 4 h of study. No statistically significant differences were found in the values of the pharmacokinetic parameters between treatments.<\/jats:p><jats:p>The half\u2010life time calculated from salivary levels was similar to the values previously reported by other authors. The percent of the oral dose excreted in saliva during 4 h of study was very low (0.1%). Secondary peaks appeared in 8 of 10 profiles. The lack of influence of salivary secretion on the pharmacokinetic parameters of Paracetamol and the low percent secreted in this fluid suggests that entero\u2010salivary recirculation is a possible physiological phenomenon undergoing after oral administration, but it is not one of the principal phenomenon that defines the pharmacokinetic of the drug. We confirm that working with salivary samples in pharmacokinetic studies of paracetamol is a useful tool. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bdd.316","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T23:01:04Z","timestamp":1034118064000},"page":"245-249","source":"Crossref","is-referenced-by-count":6,"title":["Importance of entero\u2010salivary recirculation in paracetamol pharmacokinetics"],"prefix":"10.1002","volume":"23","author":[{"given":"Paula","family":"Schaiquevich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Niselman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Modesto","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,8,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb05580.x"},{"key":"e_1_2_1_3_2","first-page":"164","article-title":"Bioequivalence study of paracetamol in saliva","author":"Fagiolino P","year":"1994","journal-title":"Eur J Drug Metab Pharmacokinet"},{"issue":"3","key":"e_1_2_1_4_2","first-page":"83","article-title":"Saliva\u2013plasma drug concentration ratios durng absorption: Theoretical considerations and pharmacokinetic implications","volume":"57","author":"Posti J","year":"1982","journal-title":"Pharm Acta Helv"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1982.tb04944.x"},{"issue":"3","key":"e_1_2_1_6_2","first-page":"241","article-title":"Bioavailability study of paracetamol by means of salivary samples","volume":"5","author":"Cardot JM","year":"1986","journal-title":"J Pharm Clin"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1973.tb10042.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1987.tb06967.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1992.tb04041.x"},{"key":"e_1_2_1_10_2","first-page":"177","article-title":"Post\u2010prandial reabsorption of paracetamol","author":"V\u00e1zquez M","year":"1993","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"e_1_2_1_11_2","first-page":"39","volume-title":"Monitorizaci\u00f3n de f\u00e1rmacos en saliva: aplicaciones biofarmac\u00e9uticas, farmacocin\u00e9ticas y terap\u00e9uticas","author":"Fagiolino P","year":"1999"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000138026"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498258309052218"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1978244420"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1973.tb08339.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061761"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079508010449"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189360"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198207020-00001"},{"key":"e_1_2_1_20_2","volume-title":"Handbook of Basic Pharmacokinetics including Clinical Applications","author":"Ritschel W","year":"1999"},{"key":"e_1_2_1_21_2","volume-title":"Pharmacokinetic and Pharmacodynamic Data Analysis System. 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