{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:30:32Z","timestamp":1779021032300,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":3530,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm. Drug Dispos."],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1002\/bdd.487","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T10:46:27Z","timestamp":1135161987000},"page":"93-102","source":"Crossref","is-referenced-by-count":31,"title":["Intestinal absorption and presystemic disposition of sildenafil citrate in the rabbit: evidence for site-dependent absorptive clearance"],"prefix":"10.1002","volume":"27","author":[{"given":"Mohammed A.","family":"Osman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal M.","family":"El Maghraby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen A.","family":"Hedaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006]]},"reference":[{"key":"10.1002\/bdd.487-BIB1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5414\/CPP40393","volume":"40","author":"Vitezic","year":"2002","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1002\/bdd.487-BIB2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1517\/14656566.4.3.397","volume":"4","author":"Carson","year":"2003","journal-title":"Expert Opin Pharmacother"},{"key":"10.1002\/bdd.487-BIB3","doi-asserted-by":"crossref","first-page":"13s","DOI":"10.1046\/j.06-5251.2001.00028.x","volume":"53","author":"Muirhead","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"10.1002\/bdd.487-BIB4","doi-asserted-by":"crossref","first-page":"5s","DOI":"10.1046\/j.0306-5251.2001.00027.x","volume":"53","author":"Nichols","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"10.1002\/bdd.487-BIB5","first-page":"18","volume":"75","author":"De Siati","year":"2003","journal-title":"Arch Ital Urol Androl"},{"key":"10.1002\/bdd.487-BIB6","first-page":"156","volume-title":"Principles and Perspectives in Drug Bioavailability","author":"Kaplan","year":"1979","unstructured":". In vitro, in situ, and in vivo models in bioavailability assessment. In Principles and Perspectives in Drug Bioavailability, , . (eds). S. Karger: Basel, Switzerland, 1979; 156\u2013191."},{"key":"10.1002\/bdd.487-BIB7","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1023\/A:1015817426713","volume":"8","author":"Riad","year":"1991","journal-title":"Pharm Res"},{"key":"10.1002\/bdd.487-BIB8","doi-asserted-by":"crossref","first-page":"s350","DOI":"10.1023\/A:1015890918883","volume":"9","author":"Zhong","year":"1992","journal-title":"Pharm Res"},{"key":"10.1002\/bdd.487-BIB9","author":"Osman","unstructured":", . In situ absorption of the antiviral nucleoside stavudine (D4T) from rabbit intestine. In Alexandria Second International Conference of Pharmaceutical Sciences and Technology 2000; Abstract book, 56."},{"key":"10.1002\/bdd.487-BIB10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gut.14.9.683","volume":"141","author":"Loehry","year":"1973","journal-title":"Gut"},{"key":"10.1002\/bdd.487-BIB11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jps.2600660117","volume":"66","author":"Maeda","year":"1977","journal-title":"J Pharm Sci"},{"key":"10.1002\/bdd.487-BIB12","first-page":"1671","volume-title":"Physiology of the Gastrointestinal Tract","volume":"2","author":"Granger","year":"1987","unstructured":", , . The microcirculation and intestinal transport. In Physiology of the Gastrointestinal Tract, 2nd edn, (ed.). Raven Press: New York, 1987; vol. 2, 1671\u20131697."},{"key":"10.1002\/bdd.487-BIB13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0022-5193(81)90306-4","volume":"89","author":"Amidon","year":"1981","journal-title":"J Theor Biol"},{"key":"10.1002\/bdd.487-BIB14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0378-5173(80)90140-4","volume":"4","author":"Komiya","year":"1980","journal-title":"Int J Pharm"},{"key":"10.1002\/bdd.487-BIB15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0378-5173(80)90048-4","volume":"5","author":"Ni","year":"1980","journal-title":"Int J Pharm"},{"key":"10.1002\/bdd.487-BIB16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3109\/03639048309046315","volume":"9","author":"Ho","year":"1983","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1002\/bdd.487-BIB17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jps.10002","volume":"91","author":"Gan","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1002\/bdd.487-BIB18","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1152\/ajplegacy.1966.211.5.1137","volume":"211","author":"Lifson","year":"1966","journal-title":"Am J Physiol"},{"key":"10.1002\/bdd.487-BIB19","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1152\/ajplegacy.1968.215.2.444","volume":"215","author":"Lifson","year":"1968","journal-title":"Am J Physiol"},{"key":"10.1002\/bdd.487-BIB20","first-page":"f469","volume":"241","author":"Bresler","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1002\/bdd.487-BIB21","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0090-9556(24)15055-6","volume":"28","author":"Warrington","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"10.1002\/bdd.487-BIB22","doi-asserted-by":"crossref","first-page":"13s","DOI":"10.1046\/j.0306-5251.2001.00030.x","volume":"53","author":"Wilner","year":"2002","journal-title":"Br J Clin Pharmacol"},{"key":"10.1002\/bdd.487-BIB23","doi-asserted-by":"crossref","first-page":"37s","DOI":"10.1046\/j.0306-5251.2001.00031.x","volume":"53","author":"Muirhead","year":"2002","journal-title":"Br J Clin Pharmacol"}],"container-title":["Biopharmaceutics & Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.487","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/bdd.487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:38:26Z","timestamp":1736185106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"URL":"https:\/\/doi.org\/10.1002\/bdd.487","relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}