{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:39:38Z","timestamp":1791103178487,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T00:00:00Z","timestamp":1149638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study was aimed at the preparation and performance evaluation of Intacglobin<jats:sup>\u00ae<\/jats:sup>\u2010loaded liposomes for selective drug presentation to the lungs. Egg phosphatidylcholine\u2010 and cholesterol\u2010based liposomes (1:1 and 1:0.25 mol\/mol) were prepared by a dehydration\u2013rehydration procedure. A tissue distribution study after single intranasal administration of 0.5 \u00b5Ci <jats:sup>125<\/jats:sup>I\u2010Intacglobin<jats:sup>\u00ae<\/jats:sup>\u2010loaded liposomes was conducted in Balb\/c mice. The efficiencies of drug entrapment (30%) and the average diameters did not differ significantly between the two liposome formulations. However, liposomes composed of an increased cholesterol amount showed a lower <jats:italic>in vitro<\/jats:italic> drug release rate. The airway penetration efficiency of the liposomal formulation was determined by the cumulative percentage of the dose reaching the lungs (<jats:italic>AUC<\/jats:italic>) and its sojourn time therein, and were 1.7\u2010 and 2.2\u2010times higher compared with the plain <jats:sup>125<\/jats:sup>I\u2010 Intacglobin<jats:sup>\u00ae<\/jats:sup> solution\u2010based formulation, respectively. A significantly greater (<jats:italic>p<\/jats:italic>&lt;0.001) drug localization index after 24 h was found at the lungs in comparison with the other tissues (<jats:italic>p<\/jats:italic>&lt;0.01), although similar values were detected between groups following administration of either liposomes or control solutions, despite the formulations attributes. In conclusion, it is suggested that longer Intacglobin exposure at the pulmonary region is observed after administration of the liposomal formulation. The results open future perspectives in assessing local passive immunization for the treatment of respiratory infectious diseases. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bdd.511","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T12:03:21Z","timestamp":1149681801000},"page":"275-283","source":"Crossref","is-referenced-by-count":17,"title":["Biodistribution of liposome\u2010entrapped human gamma\u2010globulin"],"prefix":"10.1002","volume":"27","author":[{"given":"Mar\u00eda A.","family":"Garc\u00eda\u2010Santana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Duconge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E.","family":"Sarmiento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E.","family":"Lanio\u2010Ru\u00edz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Becquer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Izquierdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Acosta\u2010Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.12.3.383","article-title":"Intranasal antibody prophylaxis for protection against viral disease","volume":"12","author":"Welztin R","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.47.276"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805123181904"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1983.tb02929.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/515688"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15688"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.5.1123"},{"key":"e_1_2_1_9_2","first-page":"280","article-title":"Enhanced protection against respiratory influenza A infection in mice by liposome\u2010encapsulated antibody","volume":"81","author":"Wong JP","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00680-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1184-979"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/194495a0"},{"key":"e_1_2_1_13_2","first-page":"142","volume-title":"Te\u00e9cnicas de Microscop\u00eda Electr\u00f3nica en Biolog\u00eda","author":"Gonz\u00e1les\u2010Santander R","year":"1969"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.57.1445"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/08982100009031096"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1860591"},{"key":"e_1_2_1_17_2","volume-title":"Liposomes: Practical Approach","author":"New RRC","year":"1994"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(02)02529-1"},{"key":"e_1_2_1_19_2","first-page":"56","article-title":"Systematic intranasal drug delivery: concepts and applications","volume":"2","author":"Wermeling DP","year":"2002","journal-title":"Drug Deliv Tech"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00188-8"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.4143"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdd.511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T13:30:25Z","timestamp":1700055025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,7]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1002\/bdd.511"],"URL":"https:\/\/doi.org\/10.1002\/bdd.511","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,7]]}}}