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After oral administration of warfarin at a dose of 2 mg\/kg to male rats with oxolamine at doses of 10 and 50 mg\/kg, the <jats:italic>AUC<\/jats:italic> values of warfarin were significantly greater than the controls (254 and 330 versus 180 \u00b5g h\/ml). However, the <jats:italic>AUC<\/jats:italic> values of warfarin were not affected by oxolamine in female rats. This could be due to inhibition of CYP2B1, 2C11 and 3A2 by oxolamine in male rats, since warfarin was metabolized via CYP1A1, 2B1, 2C6, 2C11 and 3A2 in rats and CYP2B1 is male dominant, and CYP2C11 and 3A2 are male specific. Therefore, phenytoin, torasemide and clarithromycin (mainly metabolized via CYP2B1\/2, 2C11 and 3A2 in rats, respectively) were administered intravenously to male rats with or without oral oxolamine. After oral oxolamine at doses of 10 and 50 mg\/kg, the <jats:italic>AUC<\/jats:italic> of phenytoin was significantly greater (1280 and 1640 versus 938 \u00b5g min\/ml), however, the <jats:italic>AUC<\/jats:italic> values of torasemide and clarithromycin were independent of oxolamine. The above data suggest that the significantly greater <jats:italic>AUC<\/jats:italic> of oral warfarin with oral oxolamine could be due to inhibition of CYP2B1\/2 by oxolamine in male rats. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bdd.538","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T11:15:51Z","timestamp":1171365351000},"page":"125-133","source":"Crossref","is-referenced-by-count":10,"title":["Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats"],"prefix":"10.1002","volume":"28","author":[{"given":"Xuan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan G.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199550020-00003"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(96)00140-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(83)90045-0"},{"key":"e_1_2_1_5_2","first-page":"122","volume-title":"Cytochromes P450. 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