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One day after CCl<jats:sub>4<\/jats:sub>administration, indicators of necrosis (alanine aminotransferase), cholestasis (\u03b3\u2010glutamyl transpeptidase) and regeneration (\u03b1\u2010fetoprotein) were significantly increased; these effects were reversed after 3 days. In nonintoxicated rats,<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>was 43.83 \u00b1 4.95 min,<jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>was 0.37 \u00b1 0.04 l\/kg,<jats:italic>Cl<\/jats:italic>was 129.21 \u00b1 9.20 ml\/min kg,<jats:italic>AUC<\/jats:italic><jats:sub>i.v.<\/jats:sub>was 25.62 \u00b1 1.45 \u00b5g\/min ml, and<jats:italic>AUC<\/jats:italic><jats:sub>p.o.<\/jats:sub>was 20.21 \u00b1 1.03. One day after intoxication, when the liver was damaged and regenerating, the metabolism was decreased: diclofenac<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>was increased to 258.21 \u00b1 30.80 min but<jats:italic>V<\/jats:italic><jats:sub>d<\/jats:sub>did not change significantly, therefore<jats:italic>Cl<\/jats:italic>was reduced to 32.81 \u00b1 3.38 ml\/min kg. By day 3 after intoxication, liver function, regeneration and pharmacokinetics returned to normal. The results show that liver damage and regeneration increases the bioavailability by decreasing elimination. The present observations suggest that reduction of the pharmacokinetic parameters may lead to drug accumulation in the regenerating\u2010damaged liver with an attendant possible increase in toxic effects. The results in rats, also suggest that once hepatic injury is finished and regeneration is complete, diclofenac can be administered normally. 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