{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:12:18Z","timestamp":1775909538217,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T00:00:00Z","timestamp":1189382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study compares plasma disposition kinetics of ivermectin and moxidectin after oral administration to beagle dogs experimentally infected with the filarial parasite, <jats:italic>Brugia pahangi<\/jats:italic>. Sixteen dogs were selected and randomly allocated into two groups of eight dogs each. Animals in each group received either ivermectin or moxidectin by oral route at a dose of 250 \u00b5g\/kg. Blood samples were collected from 0.5 h up to 56 days post\u2010treatment and the plasma was analysed by high performance liquid chromatography (HPLC). The obtained data were analysed by compartmental and non\u2010compartmental pharmacokinetic techniques. Peak plasma concentrations (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) of 234.0 \u00b1 64.3 ng\/ml (mean \u00b1 SD) were obtained for moxidectin and 132.6 \u00b1 43.0 ng\/ml for ivermectin. The terminal elimination half\u2010life was significantly (<jats:italic>p<\/jats:italic>&lt;0.01) longer in the moxidectin treated group (621.3 \u00b1 149.3 h) than for ivermectin treated group (80.3 \u00b1 29.8 h). A significantly (<jats:italic>p<\/jats:italic>&lt; 0.01) larger <jats:italic>V<\/jats:italic><jats:sub>ss<\/jats:sub>\/<jats:italic>F<\/jats:italic> was obtained for moxidectin (19.21 \u00b1 3.61 l\/kg) compared with ivermectin (5.35 \u00b1 1.29 l\/kg). The mean estimates of <jats:italic>CL<\/jats:italic>\/<jats:italic>F<\/jats:italic> of moxidectin and ivermectin were 0.0220 \u00b1 0.00381 and 0.0498 \u00b1 0.0179 l\/h\/kg, respectively. The comparative plasma disposition kinetics of ivermectin and moxidectin in dogs is reported for the first time. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bdd.572","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T17:47:07Z","timestamp":1189446427000},"page":"431-438","source":"Crossref","is-referenced-by-count":57,"title":["Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs"],"prefix":"10.1002","volume":"28","author":[{"given":"Sayer I.","family":"Al\u2010Azzam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuei\u2010Ju","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Dzimianski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"McCall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(94)00743-V"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00062.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2746\/042516401776254835"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1997.00825.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(93)90143-B"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01839009"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00357-5"},{"key":"e_1_2_1_9_2","first-page":"139","article-title":"Efficacy of moxidectin for the prevention of adult heartworm (Dirofilaria immitis) infection in dogs","volume":"43","author":"Genchi C","year":"2001","journal-title":"Parasitologia"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.313"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1994.tb00271.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.08.026"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(02)00120-6"},{"key":"e_1_2_1_14_2","unstructured":"WinNonlin Users Guide Version 4. 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