{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:51:59Z","timestamp":1767894719475,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopharm &amp; Drug Disp"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study aimed to develop a novel colon\u2010targeting microsphere of beclomethasone dipropionate (cMS\/BDP) with enhanced pharmacological effect of BDP in the colon. cMS\/BDP was prepared using Eudragit\n                    <jats:sup>\u00ae<\/jats:sup>\n                    S\u2010100 by the emulsion solvent diffusion method, and its physicochemical properties were characterized. A pharmacokinetic study was conducted to assess systemic exposure and colon distribution of BDP after oral administration of cMS\/BDP to rats. A pharmacodynamic study was carried out to evaluate the anti\u2010inflammatory effect of cMS\/BDP after its oral administration to ulcerative colitis model rats. The particle size of cMS\/BDP was calculated to be ca. 20\u00a0\u03bcm, and most BDP in cMS\/BDP might be in an amorphous state. In dissolution tests, cMS\/BDP showed pH\u2010dependent release behavior of BDP and marked BDP release at pH 7.4. After oral administration of cMS\/BDP (5 mg\u2010BDP\/kg) to rats, BDP was rapidly metabolized to beclomethasone 17\u2010monopropionate (17\u2010BMP, a BDP metabolite) in the gastrointestinal tract and liver, and relative oral bioavailability of 17\u2010BMP in the cMS\/BDP group was calculated to be ca. 4.8% compared with that in the BDP solution group. The tissue\u2010to\u2010plasma partition coefficient value, an index of colon distribution, for cMS\/BDP was found to be 15\u2010fold higher than that for BDP solution. In the cMS\/BDP (50\u00a0\u03bcg\/kg) group, colonic myeloperoxidase activity and hyperplasia of the submucosa were negligibly elevated. From these findings, the cMS approach for BDP would be a promising dosage option for strategic colon delivery, leading to an improved therapeutic potential of BDP with a wide safety margin.\n                  <\/jats:p>","DOI":"10.1002\/bdd.70005","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:08:51Z","timestamp":1744178931000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Enteric Microsphere of Beclomethasone Dipropionate With Colon Delivery and Enhancement of Anti\u2010Inflammatory Effects"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-9400","authenticated-orcid":false,"given":"Atsushi","family":"Uchida","sequence":"first","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka  Suruga\u2010ku Japan"},{"name":"Department of Pharmacy University of Yamanashi Hospital  Chuo\u2010city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka  Suruga\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsubasa","family":"Kihara","sequence":"additional","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka  Suruga\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Yamada","sequence":"additional","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka  Suruga\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka  Suruga\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Onoue","sequence":"additional","affiliation":[{"name":"Laboratory of Biopharmacy School of Pharmaceutical Sciences University of Shizuoka  Suruga\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"470","article-title":"De\u2010Esterified Tragacanth Microspheres Loaded into Eudragit S\u2010100 Coated Capsules for Colon\u2010Targeted Delivery","volume":"17","author":"Ahmadi E.","year":"2018","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116028"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/japtr.JAPTR_26_19"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20105173(88)90073\u20107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102125.1998.00782.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.028"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306\u20105251.2001.01374.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.05.948"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"247","article-title":"Inflammatory Bowel Disease Part 1: Ulcerative Colitis\u2010\u2010Pathophysiology and Conventional and Alternative Treatment Options","volume":"8","author":"Head K. A.","year":"2003","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201005\u2010021139"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009333209"},{"issue":"2","key":"e_1_2_8_13_1","first-page":"267","article-title":"Analysis of Blood Concentrations Following Oral Administration of Beclomethasone Dipropionate for Gut GVHD","volume":"37","author":"Ito T.","year":"2010","journal-title":"Gan to kagaku ryoho. Cancer & chemotherapy"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.41"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.08.032"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0090\u20109556(25)06742\u2010x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710\u20101492\u20109\u201030"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2011.05.034"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2008.08.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166455"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705489"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071504"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2014.10.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2010.24"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.202556"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639040903092319"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.22377\/ajp.v2i2.186"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.1944"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0142\u20109612(03)00528\u20103"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200001000-00010"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.074"}],"container-title":["Biopharmaceutics &amp; Drug Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdd.70005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:07:31Z","timestamp":1767874051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdd.70005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/bdd.70005"],"URL":"https:\/\/doi.org\/10.1002\/bdd.70005","archive":["Portico"],"relation":{},"ISSN":["0142-2782","1099-081X"],"issn-type":[{"value":"0142-2782","type":"print"},{"value":"1099-081X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}