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The apparent clearance (CL\n                    <jats:italic>\/F<\/jats:italic>\n                    ) of BET was first evaluated using traditional allometric scaling methods, indicating that CL\n                    <jats:italic>\/F<\/jats:italic>\n                    reasonably correlates with body weight (BW) with a power coefficient of 1.0 and\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.93. A minimal physiological\u2010based pharmacokinetic (mPBPK) model containing blood, two lumped tissue compartments, perfusion rate limited distribution, first\u2010order absorption or prodrug conversion when needed, and utilizing the physiological and anatomical sizes of each of five species was implemented. The BET PK profiles were reasonably captured by the mPBPK model in the joint fitting analysis with a conserved partition coefficient (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>p<\/jats:italic>\n                    <\/jats:sub>\n                    \u00a0=\u00a00.99) and species\u2010specific CL values. An allometric two\u2010compartment model was also utilized and compared. Overall, the distribution properties of BET were reasonably conserved across species, but species\u2010specific absorption rates and clearances provided best joint fitting of PK data across most species.\n                  <\/jats:p>","DOI":"10.1002\/bdd.70017","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:34:27Z","timestamp":1763458467000},"page":"198-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Across\u2010Species Meta\u2010Analysis of Betamethasone Pharmacokinetics Utilizing a Minimal PBPK Model"],"prefix":"10.1002","volume":"46","author":[{"given":"Congyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences State University of New York at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-0550","authenticated-orcid":false,"given":"William J.","family":"Jusko","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences State University of New York at Buffalo  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.028829"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.120250"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108236"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(77)90466\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01062336"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/074823379701300401"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0460379"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928\u2010012\u20109280\u20102"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40005\u2010025\u201000770\u20106"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.38212\/2224\u20106614.2588"},{"key":"e_1_2_9_12_1","article-title":"ADAPT 5 User's Guide: Pharmacokinetics\/Pharmacodynamics Systems Analysis Software","author":"D'Argenio D. 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