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In recent years, various research has been done on reliable and effective treatment methods for the most common neurodegenerative diseases such as Parkinson's, Alzheimer, and Migraine diseases. Different neurodegenerative disorders such as Huntington's disease, Alzheimer's disease, Parkinson's disease, amyotrophic, Lewy body disease can be treated by curcumin, which is a strong antioxidant polyphenol with neuroprotective and anti\u2010amyloid properties. However, Blood\u2010brain barrier (BBB) and blood cerebrospinal fluid barrier restricts the permeation of curcumin to the brain leads poor distribution of the drug in brain tissue. The intranasal pathway holds promise for enhancing the treatment of CNS disorders since it bypasses the BBB and increases the brain bioavailability of drug. As nanotechnology continues to improve, research on the delivery of drug through intranasal route has grown significantly in last 10 years. Several nanocarriers have been developed such as nano\u2010emulsions, microspheres, dendrimers, liposomes, carbon\u2010based nanoformulation, and nanoparticles to deliver curcumin to the brain via intranasal route for the treatment of neurodegenerative diseases. This study provided a thorough analysis of several curcumin nano\u2010formulations used in intranasal pathway as a novel treatment for neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/bdd.70021","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T10:47:05Z","timestamp":1767437225000},"page":"12-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nose to Brain Delivery of Curcumin Loaded Therapeutic Nanostructures for Neurodegenerative Diseases"],"prefix":"10.1002","volume":"47","author":[{"given":"Rupsikha","family":"Kalita","sequence":"first","affiliation":[{"name":"Advanced Drug Delivery Laboratory, Department of Pharmaceutics School of Pharmaceutical Sciences Girijananda Chowdhury University  Guwahati India"},{"name":"Department of Pharmaceutical Sciences Dibrugarh University  Dibrugarh 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