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Therefore, this study investigated the impact of 19 xenobiotic drugs (e.g. dexamethasone, vinblastine, bilobalide and cocaine) on the expression of ten miRNAs (miR\u201018a, \u201027a, \u201027b, \u2010124a, \u2010148a, \u2010324\u20103p, \u2010328, \u2010451, \u2010519c and \u22121291) in MCF\u20107, Caco\u20102, SH\u2010SY5Y and BE(2)\u2010M17 cell systems. The data revealed that miRNAs were differentially expressed in human cell lines and the change in miRNA expression was dependent on the drug, as well as the type of cells investigated. Notably, treatment with bilobalide led to a 10\u2010fold increase of miR\u201027a and a 2\u2010fold decrease of miR\u2010148a in Caco\u20102 cells, but no change of miR\u201027a and a 2\u2010fold increase of miR\u2010148a in MCF\u20107 cells. Neuronal miR\u2010124a was generally down\u2010regulated by psychoactive drugs (e.g. cocaine, methadone and fluoxetine) in BE(2)\u2010M17 and SH\u2010SY5Y cells. Dexamethasone and vinblastine, inducers of drug\u2010metabolizing enzymes and transporters, suppressed the expression of miR\u201027b, \u2010148a and \u2212451 that down\u2010regulate the enzymes and transporters. These findings should provide increased understanding of the altered gene expression underlying drug disposition, multidrug resistance, drug\u2013drug interactions and neuroplasticity. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bdd.764","type":"journal-article","created":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T04:14:41Z","timestamp":1311826481000},"page":"355-367","source":"Crossref","is-referenced-by-count":44,"title":["<scp>MicroRNA<\/scp> expression is differentially altered by xenobiotic drugs in different human cell lines"],"prefix":"10.1002","volume":"32","author":[{"given":"Alice C.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo, SUNY  Buffalo NY 14260 USA"},{"name":"Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences University of Sao Paulo  Sao Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo, SUNY  Buffalo NY 14260 USA"},{"name":"Institute of 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