{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:43:06Z","timestamp":1792204986399,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273054"],"award-info":[{"award-number":["81273054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20120101110107"],"award-info":[{"award-number":["20120101110107"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["20020903"],"award-info":[{"award-number":["20020903"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2012M510233"],"award-info":[{"award-number":["2012M510233"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate\u2010resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Chinese population with highly incident NTDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010seven aborted fetuses with NTDs during the third trimester were cases and 142 healthy newborns were controls. Placental fatty acid composition, eicosanoids, and cytokines were determined by standard methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The placental C20:4n\u20106\/C20:5n\u20103 and thromboxane B<jats:sub>2<\/jats:sub> (TXB<jats:sub>2<\/jats:sub>)\/6\u2010keto\u2010prostaglandin F<jats:sub>1\u03b1<\/jats:sub> (6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub>) ratios were significantly higher for cases than controls (<jats:italic>p<\/jats:italic> &lt; 0.001 and 0.05, respectively). For the top versus the lowest tertiles of placental C20:4n\u20106\/C20:5n\u20103 and TXB<jats:sub>2<\/jats:sub>\/6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub>, odds ratios for NTD occurrence were 3.79 (95% confidence interval, 1.60\u20138.96) (<jats:italic>p<\/jats:italic> for trend &lt; 0.01) and 5.52 (95% confidence interval, 2.07\u201314.74) (<jats:italic>p<\/jats:italic> for trend &lt; 0.001), respectively, adjusted for fetal sex as well as maternal age, occupation, parity, smoking, passive smoking, periconceptional folate supplementation, conception season, and tea drinking. The C20:4n\u20106\/C20:5n\u20103 and TXB<jats:sub>2<\/jats:sub>\/6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub> ratios were positively correlated (r = 0.14; <jats:italic>p<\/jats:italic> &lt; 0.05). The proportions of C18:2n\u20106, C18:3n\u20106, C20:3n\u20106, C18:3n\u20103, C20:3n\u20103, C20:5n\u20103, and C22:5n\u20103 were significantly lower in cases than controls, and all negatively associated with NTD occurrence (tertile\u2010specific odds ratios); after adjustment for the potential confounders, these associations remained significant (<jats:italic>p<\/jats:italic> for trend &lt; 0.05) except for C20:3n\u20103.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High placental ratios of C20:4n\u20106\/C20:5n\u20103 and TXB<jats:sub>2<\/jats:sub>\/6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub> are risk factors for neural tube defects.Birth Defects Research 109:550\u2013563, 2017.\u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1003","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T07:55:34Z","timestamp":1490428534000},"page":"550-563","source":"Crossref","is-referenced-by-count":12,"title":["High Ratios of C20:4n\u20106\/C20:5n\u20103 and Thromboxane B<sub>2<\/sub>\/6\u2010Keto\u2010Prostaglandin F<sub>1\u03b1<\/sub> in Placenta Are Potential Risk Contributors for Neural Tube Defects: A Case\u2013Control Study in Shanxi Province, China"],"prefix":"10.1002","volume":"109","author":[{"given":"Kelei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences Beijing Normal 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