{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T06:01:36Z","timestamp":1780725696842,"version":"3.54.1"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"LAPROFF S.A. Professional Pharmaceutical Laboratories"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This investigation determines the nutritional state of serum and red blood cell (RBC) folate concentration and their relation with intake of folate, B<jats:sub>6<\/jats:sub>,and B<jats:sub>12<\/jats:sub>, with serum vitamin B<jats:sub>12<\/jats:sub>, and with genetic variants after provision of 400 \u03bcg\/day of folic acid for 3 months to a group of 34 Colombian women of reproductive age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated nutrient intake using 24\u2010hr recall, assessing the levels of serum folate, RBC folate, serum B<jats:sub>12<\/jats:sub>, and homocysteine, as well as determining genetic variants of the enzyme<jats:italic>MTHFR<\/jats:italic>(C677T and A1298C) and<jats:italic>C\u03b2S<\/jats:italic>(844ins68pb).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results show that following intake of 400 \u03bcg\/day of folic acid, the risk of folate deficiency as seen in regular dietary intake disappears and the nutritional status of this nutrient is increased (<jats:italic>p<\/jats:italic>&lt; 0.001). With respect to vitamin B<jats:sub>12,<\/jats:sub>the risk of serum deficiency with folic acid consumption increased slightly, and those that were found to be B<jats:sub>12<\/jats:sub>deficient after supplementation also had decreased levels of serum homocysteine. Genetic factors did not influence the nutritional status of folate, although an association was found between the intake of nutrients and biochemical indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the results of our study, subsequent studies evaluating folic acid supplementation should also consider evaluating the status of B<jats:sub>12<\/jats:sub>and B<jats:sub>6<\/jats:sub>, and serum and RBC folate, as they participate interdependently in the cycle of folate and methionine and in homocysteine metabolism.Birth Defects Research 109:564\u2013573, 2017.\u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1004","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T13:16:38Z","timestamp":1489583798000},"page":"564-573","source":"Crossref","is-referenced-by-count":10,"title":["Study Exploring the Effects of Daily Supplementation with 400 \u03bcg of Folic Acid on the Nutritional Status of Folate in Women of Reproductive Age"],"prefix":"10.1002","volume":"109","author":[{"given":"Laidy D.","family":"Arias","sequence":"first","affiliation":[{"name":"Research Group in Food and Human Nutrition School of Nutrition and Dietetics, Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz E.","family":"Parra","sequence":"additional","affiliation":[{"name":"Research Group in Food and Human Nutrition School of Nutrition and Dietetics, Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica M.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Research Group in Food and Human Nutrition School of Nutrition and Dietetics, Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Research Group in Food and Human Nutrition School of Nutrition and Dietetics, Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany G.","family":"Duque","sequence":"additional","affiliation":[{"name":"Independent Global Nutrition Consultant Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz M.","family":"Manjarr\u00e9s","sequence":"additional","affiliation":[{"name":"Research Group in Food and Human Nutrition School of Nutrition and Dietetics, Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200108"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28427"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902072106"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.25100\/cm.v37i1.411","article-title":"Homociste\u00edna y polimorfismos de cistationina \u03b2 sintasa y metilentetrahidrofolatos reductasa en poblaci\u00f3n sana de Colombia","volume":"37","author":"Bermudez M","year":"2006","journal-title":"Colomb Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/470656"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60996-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0379572115585772"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.1.99"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.2.353"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S129"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-015-0456-4"},{"key":"e_1_2_6_13_1","first-page":"115","article-title":"Uso periconcepcional de \u00e1cido f\u00f3lico en centros de salud de la Jurisdicci\u00f3n Sanitaria de la Delegaci\u00f3n Tlalpan","volume":"146","author":"Can\u00fan\u2010Serrano S","year":"2009","journal-title":"Gac M\u00e9d Mex"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07247-4"},{"key":"e_1_2_6_15_1","first-page":"CD007950","article-title":"Effects and safety of periconceptional folate supplementation for preventing birth defects","volume":"10","author":"De\u2010Regil LM","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.83.3.708"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1622"},{"key":"e_1_2_6_18_1","unstructured":"FAO.2014.Organizaci\u00f3n de las Naciones Unidas para la alimentaci\u00f3n y la agricultura. 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