{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:34:39Z","timestamp":1789842879070,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102178"],"award-info":[{"award-number":["81102178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573225"],"award-info":[{"award-number":["81573225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7172115"],"award-info":[{"award-number":["7172115"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Orofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta\u2010analysis to estimate the prevalence of OFCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The systematic review and meta\u2010analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta\u2010analysis, including subgroup analysis, was conducted to estimate the pooled prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 41 studies published between 1986 and 2015 were included in our analysis. The sample size ranged from 2,586 to 4,611,808 live births. The random\u2010effects model of meta\u2010analysis showed that the overall prevalence of OFCs in China was 1.4 per 1000 live births (95% confidence interval [CI], 1.1\u20131.7). In subgroup analysis based on geographic regions, we found that OFC prevalence in Southwest (2.3 per 1000 live births, 95% CI, 1.1\u20134.7) was higher than that in other regions of China. There were no significant time trends of OFCs during the study period (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value = 0.47).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The overall prevalence of OFCs in China was 1.4 per 1000 live births. No significant secular trend of prevalence has been found in this analysis. Further studies need to be conducted to explore the etiology of OFC to better control the risk of this common birth defect. Birth Defects Research 109:1011\u20131019, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.1043","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T03:33:53Z","timestamp":1498016033000},"page":"1011-1019","source":"Crossref","is-referenced-by-count":53,"title":["Prevalence of Orofacial Clefts among Live Births in China: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-5355","authenticated-orcid":false,"given":"Mengying","family":"Wang","sequence":"first","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Peking University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University School of Stomatology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center Beijing China"},{"name":"Key Laboratory of Reproductive Health Ministry of Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri H.","family":"Beaty","sequence":"additional","affiliation":[{"name":"Johns Hopkins University, School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/08-093.1"},{"key":"e_1_2_6_3_1","first-page":"4688","article-title":"Analysis of birth defects in Pudong New Area, Shanghai City from 2010 to 2011 [in Chinese]","volume":"28","author":"Chen C","year":"2013","journal-title":"Zhong Guo Fu You Bao Jian"},{"key":"e_1_2_6_4_1","first-page":"208","article-title":"Investigation of birth defects of perinatal newborn in Kaiping City [in Chinese]","volume":"16","author":"Chen J","year":"2004","journal-title":"Zhong Guo Min Kang Yi Xue Za Zhi"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1179\/000349803125002823"},{"key":"e_1_2_6_6_1","first-page":"e58","article-title":"A multisite study of oral clefts and associated abnormalities in Thailand: the epidemiologic data","volume":"3","author":"Chowchuen B","year":"2016","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2002)039<0392:FCAPDA>2.0.CO;2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38106.559120.7C"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(2000)037<0274:DEONCL>2.3.CO;2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1597\/05-167"},{"key":"e_1_2_6_11_1","first-page":"438","article-title":"The monitoring of cleft lip with or without cleft palate in China: 1996\u20102000 [in Chinese]","volume":"38","author":"Dai L","year":"2003","journal-title":"Zhong Hua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20607"},{"key":"e_1_2_6_13_1","unstructured":"EUROCAT.2014.European Surveillance of Congenital Anomalies. 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