{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:55:18Z","timestamp":1778565318681,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["304455\/2012\u20101"],"award-info":[{"award-number":["304455\/2012\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["306245\/2016\u20107"],"award-info":[{"award-number":["306245\/2016\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2018,1,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The World Health Organization has recognized the relevance of databases on craniofacial anomalies since <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bdr21123-bib-0033\"\/>. To date, there is no universal standard instrument\/database focused on risk factors, clinical and genetic data collection, and follow\u2010up that enables comparison between different populations and genotype\u2013phenotype correlation. Although studies have shown that specific genes would impact outcomes, knowledge is not sufficient to subsidize cost\u2010effectiveness strategies for diagnosis, surgical decision, and a multi\u2010professional approach toward personalized medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on a clinical genetic approach, a Web\u2010based application named <jats:italic>CranFlow\u2014Craniofacial Anomalies: Registration, Flow, and Management<\/jats:italic> has been developed. It prospectively collects clinical and genetic information for the Brazilian Database on Craniofacial Anomalies (syndromic and nonsyndromic orofacial cleft, 22q11.2 deletion syndrome, and other craniofacial related disorders). A comprehensive list of <jats:italic>CranFlow's<\/jats:italic> features is provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present preliminary results on 1546 cases already recorded and followed, which allows recognizing 10% of diagnosis changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The identification of risk factors, consistent genetic approach associated with clinical data and follow\u2010up result in valuable information to develop and improve personalized treatment and studies on genotype\u2013phenotype correlation. Adoption of <jats:italic>CranFlow<\/jats:italic> in different clinical services may support comparison between populations. This application has the potential to contribute to improvements in healthcare, quality of services, clinical and surgical outcomes, and the standard of living of individuals with craniofacial anomalies. Birth Defects Research 110:72\u201380, 2018. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1123","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T12:56:45Z","timestamp":1506430605000},"page":"72-80","source":"Crossref","is-referenced-by-count":14,"title":["<i>CranFlow<\/i>: An Application for Record\u2010Taking and Management Through the Brazilian Database on Craniofacial Anomalies"],"prefix":"10.1002","volume":"110","author":[{"given":"Roberta M.","family":"Volpe\u2010Aquino","sequence":"first","affiliation":[{"name":"Department of Medical Genetics School of Medical Sciences, State University of Campinas \u2010 Unicamp Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella L.","family":"Monlle\u00f3","sequence":"additional","affiliation":[{"name":"Clinical Genetics Service School of Medicine, University Hospital, Federal University of Alagoas \u2013 Ufal Macei\u00f3 AL Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Lustosa\u2010Mendes","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medical Sciences, State University of Campinas \u2010 Unicamp Campinas SP Brazil"},{"name":"Assistance Center for Cleft Lip and Palate \u2010 CAIF\u2010AFISSUR Curitiba PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda F.","family":"Mora","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medical Sciences, State University of Campinas \u2010 Unicamp Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes C.","family":"Fett\u2010Conte","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Medical School of S\u00e3o Jos\u00e9 do Rio Preto \u2013 FAMERP\/FUNFARME S\u00e3o Jos\u00e9 do Rio Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00eamis M.","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Medical Genetics Service Clinical Hospital of Porto Alegre \u2013 HCPA Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Center for Research and Rehabilitation of Lip and Palate Lesions \u2013 CRRLPL Centrinho Prefeito Luiz Gomes Joinville SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Tonocchi","sequence":"additional","affiliation":[{"name":"Assistance Center for Cleft Lip and Palate \u2010 CAIF\u2010AFISSUR Curitiba PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlane M.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Medical Genetics Service Hospital Infantil Albert Sabin \u2010 HIAS Fortaleza CE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute of Integral Medicine, Prof. Fernando Figueira \u2013 IMIP Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel T.","family":"Boy da Silva","sequence":"additional","affiliation":[{"name":"Pedro Ernesto University Hospital State University of Rio de Janeiro RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana A.","family":"de Rezende","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis School of Pharmaceutical Sciences; 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