{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:54:21Z","timestamp":1740178461329,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2017,10,16]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to evaluate the association of <jats:italic>TGFA Taq<\/jats:italic>I polymorphism with nonsyndromic cleft lip and\/or palate (NSCLP) in an Iranian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2013control study, 113 children with NSCLP and 209 controls were included. Genotyping of the <jats:italic>Taq<\/jats:italic>I polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A <jats:italic>p<\/jats:italic>\u2010value of &lt;0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the <jats:italic>TGFA Taq<\/jats:italic>I polymorphism, the distributions of genotypes in the NSCLP (<jats:italic>p<\/jats:italic> = 0.810) and control group (<jats:italic>p<\/jats:italic> = 0.422) were in Hardy\u2010Weinberg equilibrium. There was no statistically significant difference in the genotype distribution (<jats:italic>p<\/jats:italic> = 0.059) and allele frequency (<jats:italic>p<\/jats:italic> = 0.065) of the <jats:italic>TGFA Taq<\/jats:italic>I polymorphism in the NSCLP and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>TGFA Taq<\/jats:italic>I polymorphism was not associated with the risk of NSCLP in Iranian children. Birth Defects Research 109:1386\u20131389, 2017.\u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1125","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T08:32:10Z","timestamp":1509957130000},"page":"1386-1389","source":"Crossref","is-referenced-by-count":0,"title":["Association Study of Transforming Growth Factor Alpha <i>Taq<\/i>I Polymorphism and the Risk of Cleft Lip and\/or Palate in an Iranian Population"],"prefix":"10.1002","volume":"109","author":[{"given":"Fahimeh","family":"Bagheri","sequence":"first","affiliation":[{"name":"Orthodontist private practice Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-954X","authenticated-orcid":false,"given":"Asghar","family":"Ebadifar","sequence":"additional","affiliation":[{"name":"Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Department of Orthodontics, Faculty of Dentistry Shahid Behehsti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Khorram Khorshid","sequence":"additional","affiliation":[{"name":"Genetic Research Centre University of Social Welfare and Rehabilitation Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koorosh","family":"Kamali","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Public Health Zanjan University of Medical Sciences Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"348","article-title":"Association of genetic variation of the transforming growth factor\u2010alpha gene with cleft lip and palate","volume":"45","author":"Ardinger HH","year":"1989","journal-title":"Am J Hum 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