{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:29:52Z","timestamp":1776371392716,"version":"3.51.2"},"reference-count":101,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/02667\u20100"],"award-info":[{"award-number":["2016\/02667\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although various genes and genomic regions were described as of susceptibility for nonsyndromic oral clefts (NOC), recent reports have demonstrated significant interethnic variations in the genetic predisposition, a situation that affects the Brazilian population, one of the most admixed populations in the world. Therefore, the purpose of this review was to describe the available information on genetic risk markers for NOC in the Brazilian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of the literature was performed using LILACS, LIVIVO, PubMed, Scopus, and Web of Science databases, and studies that investigated genetic susceptibility markers for NOC in the Brazilian population were retrieved. Markers with enough statistical data were subjected to meta\u2010analysis using random\u2010 or fixed\u2010effects model with odds ratio (OR) and 95% confidence intervals (95% CI) as effect measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine studies conducted since 1999 were found, and in these 114 markers were evaluated throughout case\u2010control or family\u2010based approaches. Most of the studies were conducted with patients affected by nonsyndromic cleft lip with or without cleft palate (NSCL\u2009\u00b1\u2009P), and 79 markers (69.3%) were evaluated by a single study only. Meta\u2010analysis was performed with nine markers, and the most promising results were obtained for <jats:italic>IRF6<\/jats:italic> (rs642961), 8q24 (rs987525 and rs1530300) and <jats:italic>MTHFR<\/jats:italic> (rs1801133), which were associated with increased risk for NSCL\u2009\u00b1\u2009P, and for <jats:italic>BMP4<\/jats:italic> (rs17563) that showed a protective effect for NSCL\u2009\u00b1\u2009P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A large number of genetic markers distributed in several genes\/loci was associated with NOC in the Brazilian population, but in general the original studies included limited number of samples and unsatisfactory protocols. The classical risk markers located in <jats:italic>IRF6<\/jats:italic> and 8q24 showed promising results as well as rs1801133 in <jats:italic>MTHFR<\/jats:italic> and rs17563 in <jats:italic>BMP4<\/jats:italic>, and they should be validated in larger and multicenter studies taking in consideration the variations in the miscegenation of Brazilian population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1208","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T05:23:55Z","timestamp":1518672235000},"page":"827-839","source":"Crossref","is-referenced-by-count":28,"title":["Potential genetic markers for nonsyndromic oral clefts in the Brazilian population: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-3662","authenticated-orcid":false,"given":"Renato","family":"Assis Machado","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, School of Dentistry 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