{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:54:26Z","timestamp":1784580866308,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2018,7,17]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nonsyndromic cleft lip with or without cleft palate (NSCL\/P) is a debilitating condition that not only affects the individual, but the entire family. The purpose of this study was to investigate the association of <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> genes with NSCL\/P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve polymorphisms in\/nearby <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> were genotyped using Taqman chemistry. Our data set consisted of 3,473 individuals including 2,191 nonHispanic white (NHW) individuals (from 151 multiplex and 348 simplex families) and 1,282 Hispanic individuals (from 92 multiplex and 216 simplex families). Data analysis was performed using Family\u2010Based Association Test (FBAT), stratified by ethnicity and family history of NSCL\/P.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nominal associations were found between NSCL\/P and <jats:italic>BRCA1<\/jats:italic> in Hispanics and <jats:italic>BRCA2<\/jats:italic> in NHW and Hispanics (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Significant haplotype associations were found between NSCL\/P and both <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009\u2264\u2009.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest a modest association between <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> and NSCL\/P. Further studies in additional populations and functional studies are needed to elucidate the role of these genes in developmental processes and signaling pathways contributing to NSCL\/P.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1346","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T21:45:37Z","timestamp":1529444737000},"page":"1043-1048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>BRCA1<\/i> and <i>BRCA2<\/i> gene variants and nonsyndromic cleft lip\/palate"],"prefix":"10.1002","volume":"110","author":[{"given":"Nicholas","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Center for Craniofacial Research, UTHealth School of Dentistry at Houston Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Maili","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UTHealth McGovern Medical School Houston TX USA"},{"name":"Pediatric Research Center, UTHealth McGovern Medical School Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett T.","family":"Chiquet","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Research, UTHealth School of Dentistry at Houston Houston TX USA"},{"name":"Department of Pediatric Dentistry UTHealth School of Dentistry at Houston Houston TX USA"},{"name":"Pediatric Research Center, UTHealth McGovern Medical School Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Blanton","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and John P. Hussman Institute of Human Genomics University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline T.","family":"Hecht","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Research, UTHealth School of Dentistry at Houston Houston TX USA"},{"name":"Department of Pediatrics UTHealth McGovern Medical School Houston TX USA"},{"name":"Pediatric Research Center, UTHealth McGovern Medical School Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-6735","authenticated-orcid":false,"given":"Ariadne","family":"Letra","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Research, UTHealth School of Dentistry at Houston Houston TX USA"},{"name":"Department of Diagnostic and Biomedical Sciences UTHealth School of Dentistry at Houston Houston TX USA"},{"name":"Pediatric Research Center, UTHealth McGovern Medical School Houston 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