{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:17:06Z","timestamp":1784542626509,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas"},{"name":"Universidad Aut\u00f3noma de Chihuahua"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2018,10,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Folate plays a fundamental role for fetal development, participating in cell division, embryogenesis, and fetal growth. The fetus depends on maternal supply of folate across the placenta. The objective of this study was to compare the expression of Folate Receptor\u2010\u03b1 (FR\u2010\u03b1), Reduced Folate Carrier (RFC), and Proton Coupled Folate Transporter (PCFT) in placentas from pregnancies complicated with birth defects (BD) and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case\u2010control study, including placentas of BD\u2010complicated pregnancies (<jats:italic>n<\/jats:italic>\u2009=\u200925) and a control group (<jats:italic>n<\/jats:italic>\u2009=\u200925). We determined the placental expression of FR\u2010\u03b1, RFC, and PCFT by immunohistochemistry. Optical density was measured to obtain a relative quantification of the expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression of PCFT was greater in placentas from pregnancies complicated with BD than in those from the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). The expression of FR\u2010\u03b1 and RFC was not different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The expression of PCFT in placentas from BD\u2010complicated pregnancies is increased, possibly as an adaptive response to increase the folate flux at the maternal\u2010fetal interface.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1356","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T11:37:54Z","timestamp":1533123474000},"page":"1223-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Folate transporter expression in placenta from pregnancies complicated with birth defects"],"prefix":"10.1002","volume":"110","author":[{"given":"Sandra A.","family":"Reza\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin O.","family":"Aguirre\u2010Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"S\u00e1nchez\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Programa de Maestr\u00eda en Ciencias en Biotecnolog\u00eda, Facultad de Ciencias Qu\u00edmicas Universidad Aut\u00f3noma de Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Guerrero\u2010Salgado","sequence":"additional","affiliation":[{"name":"Programa de Maestr\u00eda en Ciencias en Biotecnolog\u00eda, Facultad de Ciencias Qu\u00edmicas Universidad Aut\u00f3noma de Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora V.","family":"Ch\u00e1vez\u2010Corral","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3455-9481","authenticated-orcid":false,"given":"Margarita","family":"Levario\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua Chihuahua 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