{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:27:11Z","timestamp":1765888031808},"reference-count":32,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2018,8,15]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the live\u2010birth prevalence, trends, correlates, and neonatal and 1\u2010year survival rates of congenital diaphragmatic hernia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a population\u2010based, retrospective cohort study design, we examined 1,025 cases of congenital diaphragmatic hernia from the 1998\u20132012 Florida Birth Defects Registry. We used Poisson and joinpoint regression models to compute prevalence ratios and temporal trends, respectively. Kaplan\u2013Meier survival curves and Cox proportional hazards regression were used to describe neonatal and 1\u2010year survival and estimate hazard ratios representing the predictors of infant survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The birth prevalence of congenital diaphragmatic hernia was 3.19 per 10,000 live births (95% confidence interval [CI]: 3.00\u20133.39); there was a 4.2% yearly increase among multiple cases only. Among all cases, maternal education less than high school (prevalence ratio: 1.25, 95% CI: 1.02\u20131.53), high school\/associate degree\/GED (prevalence ratio: 1.15, 95% CI: 1.01\u20131.32), multiple birth (prevalence ratio: 1.38, 95% CI: 1.05\u20131.81), and male sex (prevalence ratio: 1.18, 95% CI: 1.05\u20131.32) were associated with increased risk for congenital diaphragmatic hernia. The 24\u2010hr, neonatal, and 1\u2010year survival rates were 93.6%, 79.8%, and 71.2%, respectively. The highest hazard ratio of 17.87 (95% CI: 1.49\u2013213.82) was observed for neonatal mortality among cases associated with chromosomal anomalies and born &lt;37 weeks at\u2009&lt;\u20091,500\u2009g. Among isolated cases, multiple birth (hazard ratio: 0.41, 95% CI: 0.20\u20130.86) was associated with decreased 1\u2010year mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low maternal education and multiple birth may be linked to congenital diaphragmatic hernia. The trends in prevalence, epidemiologic correlates, and predictors of early survival can differ between congenital diaphragmatic hernia subtypes\u2014isolated, multiple, and chromosomal.\u00a9 2018 Wiley Periodicals, Inc. \u00a9 2018 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1357","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T08:14:56Z","timestamp":1533629696000},"page":"1107-1117","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Trends, correlates, and survival of infants with congenital diaphragmatic hernia and its subtypes"],"prefix":"10.1002","volume":"110","author":[{"given":"Rema","family":"Ramakrishnan","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health University of South Florida  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason L.","family":"Salemi","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Baylor College of Medicine  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Environmental Occupational Health, College of Public Health University of South Florida  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health University of South Florida  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"O'Rourke","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College of Public Health University of South Florida  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Obican","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology University of South Florida, Morsani College of Medicine  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell S.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Community and Family Health, College of Public Health University of South Florida  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00386-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.194"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.11.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.858691"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1652-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20620"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-006-1643-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10039"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20423"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2009.10.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2010.03.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.9.1414"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.01.073"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23329"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.2006.00016.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30126"},{"key":"e_1_2_7_20_1","volume-title":"Congenital diaphragmatic hernia overview.","author":"Pober B. 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