{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:07:56Z","timestamp":1792163276173,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2018,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>In this data brief, we examine major eye and ear anomalies (anophthalmia\/microphthalmia, anotia\/microtia, and congenital cataract) for a recent 5\u2010year birth cohort using data from 30 population\u2010based birth defects surveillance programs in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>As a special call for data for the 2018 NBDPN Annual Report, state programs reported expanded data on eye\/ear anomalies for birth years 2011\u20132015. We calculated the combined overall prevalence (per 10,000 live births) and 95% confidence intervals (CI), for the three anomalies as well as by maternal age, maternal race\/ethnicity, infant sex, laterality, presence\/absence of other major birth defects, and case ascertainment methodology utilized by the program (active vs. passive).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall prevalence estimate (per 10,000 live births) was 1.5 (95% CI: 1.4\u20131.5) for anophthalmia\/microphthalmia, 1.5 (95% CI: 1.4\u20131.6) for congenital cataract, and 1.8 (95% CI: 1.7\u20131.8) for anotia\/microtia. Congenital cataract prevalence varied little by maternal race\/ethnicity, infant sex, or case ascertainment methodology; prevalence differences were more apparent across strata for anophthalmia\/microphthalmia and anotia\/microtia. Prevalence among active vs. passive ascertainment programs was 50% higher for anophthalmia\/microphthalmia (1.9 vs. 1.2) and two\u2010fold higher for anotia\/microtia (2.6 vs. 1.2). Anophthalmia\/microphthalmia was more likely than other conditions to co\u2010occur with other birth defects. All conditions were more frequent among older mothers (40+ years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This data brief provides recent prevalence estimates for anophthalmia\/microphthalmia, congenital cataract, and anotia\/microtia that address a data gap by examining pooled data from 30 population\u2010based surveillance systems, covering a five\u2010year birth cohort of about 12.4 million births.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.1413","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T09:14:09Z","timestamp":1542359649000},"page":"1478-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Population\u2010based birth defects data in the United States, 2011\u20132015: A focus on eye and ear defects"],"prefix":"10.1002","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0461-1410","authenticated-orcid":false,"given":"Erin B.","family":"Stallings","sequence":"first","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"},{"name":"Carter Consulting, Incorporated  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Isenburg","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-0672","authenticated-orcid":false,"given":"Cara T.","family":"Mai","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-4145","authenticated-orcid":false,"given":"Rebecca F.","family":"Liberman","sequence":"additional","affiliation":[{"name":"Massachusetts Department of Public Health Center for Birth Defects Research and Prevention  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"Moore","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Canfield","sequence":"additional","affiliation":[{"name":"Texas Department of State Health Services Birth Defects Epidemiology and Surveillance Branch  Austin Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Salemi","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-401X","authenticated-orcid":false,"given":"Russell S.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Community and Family Health College of Public Health, University of South Florida  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyiesha D.","family":"Short","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"},{"name":"Oak Ridge Institute for Science and Education  Oak Ridge Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy N.","family":"Nembhard","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention, the Arkansas Children's Research Institute and the University of Arkansas for Medical Sciences Department of Epidemiology  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina E.","family":"Forestieri","sequence":"additional","affiliation":[{"name":"Division of Public Health North Carolina Department of Health and Human Services  Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Heinke","sequence":"additional","affiliation":[{"name":"Massachusetts Department of Public Health Center for Birth Defects Research and Prevention  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Alverson","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-9984","authenticated-orcid":false,"given":"Paul A.","family":"Romitti","sequence":"additional","affiliation":[{"name":"College of Public Health University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My\u2010Phuong","family":"Huynh","sequence":"additional","affiliation":[{"name":"Utah Birth Defect Network Utah Department of Health  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay E.","family":"Denson","sequence":"additional","affiliation":[{"name":"Oklahoma Birth Defects Registry Oklahoma State Department of Health  Oklahoma City Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily M.","family":"Judson","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"},{"name":"Carter Consulting, Incorporated  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-5863","authenticated-orcid":false,"given":"Philip J.","family":"Lupo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Hematology\u2010Oncology, Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the National Birth Defects Prevention Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.4.341"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20626"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.302098"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40352"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4825(92)90023-G"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23462"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20237"},{"key":"e_1_2_8_9_1","first-page":"227","article-title":"Childhood blindness in the context of VISION 2020\u2014The right to sight","volume":"79","author":"Gilbert C.","year":"2001","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0979"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23282"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-004-6880-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35888"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23329"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23461"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23098"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20211"},{"key":"e_1_2_8_18_1","unstructured":"National Birth Defects Prevention Network (NBDPN). (2015). Guidelines for conducting birth defects surveillance. Birth defects descriptions for NBDPN Core recommended and extended conditions. Retrieved fromhttps:\/\/www.nbdpn.org\/docs\/Appendix_3_1_BirthDefectsDescriptions2015_2016DEC14.pdf."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.12.026"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286580801983229"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30840"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000656X.2012.700018"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdr2.1413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.1413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T17:58:35Z","timestamp":1694282315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":22,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2018,11,15]]}},"alternative-id":["10.1002\/bdr2.1413"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1413","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"assertion":[{"value":"2018-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}