{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:58:28Z","timestamp":1777579108486,"version":"3.51.4"},"reference-count":127,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2019,12,21]],"date-time":"2019-12-21T00:00:00Z","timestamp":1576886400000},"content-version":"am","delay-in-days":385,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL065314"],"award-info":[{"award-number":["HL065314"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR140388"],"award-info":[{"award-number":["PR140388"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI13"],"award-info":[{"award-number":["PI13"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Low oxygen concentration (hypoxia) is part of normal embryonic development, yet the situation is complex. Oxygen (O<jats:sub>2<\/jats:sub>) is a janus gas with low levels signaling through hypoxia\u2010inducible transcription factor (HIF) that are required for development of fetal and placental vasculature and fetal red blood cells. This results in coupling of fetus and mother around midgestation as a functional feto\u2010placental unit (FPU) for O<jats:sub>2<\/jats:sub> transport, which is required for continued growth and development of the fetus. Defects in these processes may leave the developing fetus vulnerable to O<jats:sub>2<\/jats:sub> deprivation or other stressors during this critical midgestational transition when common septal and conotruncal heart defects (CHDs) are likely to arise. Recent human epidemiological and case\u2013control studies support an association between placental dysfunction, manifest as early onset pre\u2010eclampsia (PE) and increased serum bio\u2010markers, and CHD. Animal studies support this association, in particular those using gene inactivation in the mouse. Sophisticated methods for gene inactivation, cell fate mapping, and a quantitative bio\u2010reporter of O<jats:sub>2<\/jats:sub> concentration support the premise that hypoxic stress at critical stages of development leads to CHD. The secondary heart field contributing to the cardiac outlet is a key target, with activation of the un\u2010folded protein response and abrogation of FGF signaling or precocious activation of a cardiomyocyte transcriptional program for differentiation, suggested as mechanisms. These studies provide a strong foundation for further study of feto\u2013placental coupling and hypoxic stress in the genesis of human CHD.<\/jats:p>","DOI":"10.1002\/bdr2.1430","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T22:25:00Z","timestamp":1545431100000},"page":"1517-1530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Oxygen and lack of oxygen in fetal and placental development, feto\u2013placental coupling, and congenital heart defects"],"prefix":"10.1002","volume":"110","author":[{"given":"Elisa","family":"Llurba Olive","sequence":"first","affiliation":[{"name":"Director of the Obstetrics and Gynecology Department Sant Pau University Hospital, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Maternal and Child Health and Development Network II (SAMID II) RD16\/0022 Institute of Health Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine  Baltimore Maryland"},{"name":"Department of Pediatrics University of Maryland School of Medicine  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Reproductive Sciences University of California San Diego  San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-2227","authenticated-orcid":false,"given":"Steven A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine  Baltimore Maryland"},{"name":"Department of Physiology and Biophysics University of Maryland School of Medicine  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2660"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.07.021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169850"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.259"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12505"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.10.024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305597"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20885"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0344"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91340-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2011.0028"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)00159-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.305109"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.04.015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300139"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024600"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12252"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00373"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109478108"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.12.009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy02t2.102904"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.053603"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq200"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.03.027"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2017"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.11.008"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12460"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5399-1_84"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21373"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1704"},{"issue":"4","key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"042","DOI":"10.1016\/j.ajog.2015.08.042","article-title":"Why is placentation abnormal in preeclampsia?","volume":"213","author":"Fisher S. J.","year":"2015","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20697"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00853-2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.04.021"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2013"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0597"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam6607"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195211132472004"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.03.026"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61760-9"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111935"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.04.009"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000841"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.12.013"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.589655"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4359"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000338613.89841.c1"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210730109"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0633-x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(20010201)220:2<175::AID-DVDY1101>3.0.CO;2-F"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2665"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.06.002"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00346.2011"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482941.2017.1397699"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.167858"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22103"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-236"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht389"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12346"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41211"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.662627"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2015"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.05.013"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.06.006"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20738"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300828"},{"issue":"14","key":"e_1_2_7_68_1","first-page":"00140","article-title":"Gene\u2010environment interaction demonstrates the vulnerability of the embryonic heart","volume":"18","author":"Oreilly V. C.","year":"2014","journal-title":"Developmental Biology"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.857987"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24610"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.025437"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26002"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv251"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002810"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.01.008"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.05.026"},{"issue":"3","key":"e_1_2_7_77_1","first-page":"257","article-title":"Theory of oxygen transport to tissue","volume":"17","author":"Popel A. S.","year":"1989","journal-title":"Journal of Critical Reviews in Biomedical Engineering"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2673"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp046"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00771.2007"},{"issue":"2","key":"e_1_2_7_81_1","first-page":"283","article-title":"Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy","volume":"80","author":"Rodesch F.","year":"1992","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.02.006"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.12.007"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115839"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10077"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15970"},{"issue":"20","key":"e_1_2_7_87_1","first-page":"3271","article-title":"Placenta\u2010related complications in women carrying a foetus with congenital heart disease","volume":"29","author":"Ruiz A.","year":"2016","journal-title":"The Journal of Maternal\u2010Fetal & Neonatal Medicine"},{"issue":"15","key":"e_1_2_7_88_1","first-page":"4010","article-title":"Hypoxia\u2010inducible Factor\u20101{{alpha}} is a positive factor in solid tumor growth","volume":"60","author":"Ryan H. E.","year":"2000","journal-title":"Cancer Research"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1876-x"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509459103"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1998.tb03063.x"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00045.2008"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-033953"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.05.002"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.136820"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90275-4"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(97)90007-2"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015699.48605.08"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3001.093437"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht485"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1135"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00125.2015"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12582"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112269"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.07.017"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.05.036"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2004.06.004"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2003.11.017"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002414"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.01.016"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.19.3809"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00001.2005"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.5.4.11684"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20499"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22089"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.394"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214046110"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/19.6.537"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-10-r113"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810067106"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.08.072"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700047RR"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.03.134"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-43624-1_12"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88725"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12141"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.008"},{"issue":"4","key":"e_1_2_7_128_1","first-page":"517","article-title":"Placenta growth factor\u20101 is chemotactic, mitogenic, and angiogenic","volume":"76","author":"Ziche M.","year":"1997","journal-title":"Laboratory Investigation"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdr2.1430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.1430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/bdr2.1430","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T22:16:14Z","timestamp":1694297774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":127,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1002\/bdr2.1430"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1430","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}