{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T03:34:17Z","timestamp":1771990457385,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016, #0952PICT 2016, #3869"],"award-info":[{"award-number":["PICT 2016, #0952PICT 2016, #3869"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC and the role of AB, minimizing subjectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from the ECLAMC maternity hospitals network database. A total of 450 live and stillborn infants, born during 1967\u20132013, with AB or the LBWC were selected. A hierarchical cluster analysis was used to classify cases into homogeneous groups (sharing similar associated defects); robustness of the classification was confirmed with a discriminant analysis. The frequency of associated defects was compared among groups; those whose frequency differed significantly were included in a logistic regression to establish their association within each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cluster analysis identified two groups: a body wall defect (BWD) predominating in one, AB in the other. These groups were further divided into: BWD (cases with only BWD), AB (with only AB), BWD\u2009+\u2009AB, and NONE (with neither). Association with caudal defects and lower limb amelia was observed for BWD, with cephalic defects and upper limb amputations for BWD\u2009+\u2009AB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results, obtained with the least possible subjectivity, indicated that BWD and BWD\u2009+\u2009AB are different conditions. Since BWD specifically associates with amelia, we propose that this defect and not any limb deficiency should be considered as inclusion criterium and that it should be included in the BWD acronym as LBWC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1442","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T14:03:34Z","timestamp":1545919414000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Limb body wall complex: Its delineation and relationship with amniotic bands using clustering methods"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0840-7548","authenticated-orcid":false,"given":"Monica","family":"Rittler","sequence":"first","affiliation":[{"name":"ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Cong\u00e9nitas) at Hospital Materno Infantil Ramon Sarda Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebe","family":"Campa\u00f1a","sequence":"additional","affiliation":[{"name":"ECLAMC at CEMIC (Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas), Conicet  Buenos Aires Argentina"},{"name":"CIC (Comisi\u00f3n de Investigaciones Cient\u00edficas)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando A.","family":"Poletta","sequence":"additional","affiliation":[{"name":"ECLAMC at CEMIC (Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas), Conicet  Buenos Aires Argentina"},{"name":"INAGEMP (Instituto Nacional de Gen\u00e9tica M\u00e9dica Poblacional)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Santos","sequence":"additional","affiliation":[{"name":"CIC (Comisi\u00f3n de Investigaciones Cient\u00edficas)  Buenos Aires Argentina"},{"name":"IMBICE (Instituto Multidisciplinario de Biolog\u00eda Celular)  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Gili","sequence":"additional","affiliation":[{"name":"ECLAMC at CEMIC (Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas), Conicet  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela S.","family":"Pawluk","sequence":"additional","affiliation":[{"name":"ECLAMC at CEMIC (Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas), Conicet  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana R.","family":"Cosentino","sequence":"additional","affiliation":[{"name":"ECLAMC at CEMIC (Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas), Conicet  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Gimenez","sequence":"additional","affiliation":[{"name":"ECLAMC at CEMIC (Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas), Conicet  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge S.","family":"Lopez\u2010Camelo","sequence":"additional","affiliation":[{"name":"ECLAMC at CEMIC (Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas), Conicet  Buenos Aires Argentina"},{"name":"INAGEMP (Instituto Nacional de Gen\u00e9tica M\u00e9dica Poblacional)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","first-page":"253","article-title":"The OEIS complex (omphalocele, exstrophy, imperforate anus, spinal defects)","volume":"14","author":"Carey J. C.","year":"1978","journal-title":"Birth Defects Original Article Series"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080776"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/1932409"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80759-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20555"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38016"},{"key":"e_1_2_8_9_1","first-page":"132","article-title":"Limb\u2010body wall complex: A case series","volume":"12","author":"Luehr B.","year":"2002","journal-title":"The Journal of Maternal\u2010Fetal & Neonatal Medicine"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971212)73:2<176::AID-AJMG12>3.0.CO;2-N"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(1997)73:2<170::AID-AJMG11>3.0.CO;2-R"},{"issue":"5","key":"e_1_2_8_12_1","first-page":"171","article-title":"Body wall defects with reduction limb anomalies: A report of fifteen cases","volume":"15","author":"Pagon R. A.","year":"1979","journal-title":"Birth Defects: Original Article Series"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320470617"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(76)80013-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(65)90588-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320280302"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20339"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdr2.1442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T07:24:28Z","timestamp":1694676268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,27]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/bdr2.1442"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1442","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,27]]},"assertion":[{"value":"2018-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}