{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:23:28Z","timestamp":1771550608632,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","award":["6D02363004"],"award-info":[{"award-number":["6D02363004"]}],"id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2019,3,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between childhood asthma and central nervous system defects in offspring is poorly understood. We assessed if childhood asthma was associated with the risk of having an infant with neural tube or other nervous system defects compared with asthma during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed a longitudinal cohort of 128,060 women who were 5 years or less at study entry and later delivered an infant in Quebec, Canada (1989\u20132014). We identified women hospitalized for asthma before pregnancy, including childhood and adolescence, and determined if asthma was present during pregnancy based on obstetric records. Main outcomes were neural tube and non\u2010neural tube defects in pregnancy. We used log\u2010binomial regression models to determine risk ratios (RR) and 95% confidence intervals (CI) for the association between asthma and risk of nervous system defects, adjusting for patient characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asthma was associated with a greater risk of neural tube defects in offspring (RR 2.39, 95% CI 1.03\u20135.53) compared with no asthma, but not non\u2010neural tube defects (RR 1.10, 95% CI 0.71\u20131.71). Women whose asthma resolved before pregnancy had a greater risk of neural tube defects (RR 3.43, 95% CI 1.35\u20138.69), while women with asthma during pregnancy were at greater risk of non\u2010neural tube defects, especially microcephaly (RR 2.80, 95% CI 1.23\u20136.40).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Asthma that resolved before pregnancy was associated with an increased risk of neural tube defects in offspring but not non\u2010neural tube defects. Further investigation is needed to determine the pathophysiology connecting childhood asthma with nervous system defects in offspring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1452","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T07:57:21Z","timestamp":1547020641000},"page":"254-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prepregnancy asthma and the subsequent risk of central nervous system defects in offspring"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0459","authenticated-orcid":false,"given":"Nathalie","family":"Auger","sequence":"first","affiliation":[{"name":"Health Innovation Hub, University of Montreal Hospital Research Centre  Quebec Canada"},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Arbour","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"Kabageni","sequence":"additional","affiliation":[{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec  Quebec Canada"},{"name":"Department of Human Biology Claude Bernard University Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Healy\u2010Profit\u00f3s","sequence":"additional","affiliation":[{"name":"Health Innovation Hub, University of Montreal Hospital Research Centre  Quebec Canada"},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimina","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Health Innovation Hub, University of Montreal Hospital Research Centre  Quebec Canada"},{"name":"Bureau d'information et d'\u00e9tudes en sant\u00e9 des populations, Institut national de sant\u00e9 publique du Qu\u00e9bec  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Sherbrooke University Hospital Research Centre  Sherbrooke Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12505"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20651"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20581"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009237"},{"key":"e_1_2_7_7_1","first-page":"CD007949","article-title":"Addition of long\u2010acting beta2\u2010agonists to inhaled corticosteroids for chronic asthma in children","volume":"11","author":"Chauhan B. 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